2007
DOI: 10.1107/s1600536807049173
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9-Methyl-2,6-di-p-tolyl-2,3,6,7-tetrahydro-1H,5H-pyrimido[5,6,1-ij]quinazoline

Abstract: Key indicators: single-crystal X-ray study; T = 294 K; mean (C-C) = 0.006 Å; R factor = 0.058; wR factor = 0.065; data-to-parameter ratio = 8.4.The title compound, C 25 H 27 N 3 , possesses an essentially planar, fused tricyclic platform, from which two p-tolyl rings project on the same face to create a hydrophobic pocket. ExperimentalCrystal data C 25 H 27 N 3 M r = 369.5 Monoclinic, P2 1 =c a = 9.035 (3) Å b = 20.805 (7) Å c = 11.790 (3) Å = 110.95 (1) V = 2070 (1) Å 3 Z = 4 Mo K radiation = 0.07 mm À1 T = 2… Show more

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“…Of course, as is the case in all Tröger's base reactions, other by-products, such as 3,4-dihydroquinazolines (the products of a condensation between two anilines and two formaldehyde equivalents) [28,[56][57][58][59][60][61] and related products (for example, condensation between three anilines and four formaldehyde equivalents), [6,62] can also be formed. Clearly, the use of two different anilines in the reaction can magnify these types of impurities, which may complicate purification of the desired hybrids.…”
Section: Resultsmentioning
confidence: 99%
“…Of course, as is the case in all Tröger's base reactions, other by-products, such as 3,4-dihydroquinazolines (the products of a condensation between two anilines and two formaldehyde equivalents) [28,[56][57][58][59][60][61] and related products (for example, condensation between three anilines and four formaldehyde equivalents), [6,62] can also be formed. Clearly, the use of two different anilines in the reaction can magnify these types of impurities, which may complicate purification of the desired hybrids.…”
Section: Resultsmentioning
confidence: 99%