2004
DOI: 10.1007/s00213-004-1988-2
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?9-THC-induced cognitive deficits in mice are reversed by the GABAA antagonist bicuculline

Abstract: This is the first demonstration of which we are aware showing that GABA(A) receptors may play a necessary role in Delta(9)-THC-induced memory impairment in whole animals.

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Cited by 36 publications
(21 citation statements)
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“…In agreement, THC produces full tetrad effects in the conditional knockout mice lacking CB1R in GABAergic terminals [102]. Likewise, the GABA-A receptor antagonist bicuculline does not block THCinduced tetrad effects [103]. Interestingly, the effects of cannabinoids on long-term memory and working memory have been associated to CB1R in GABAergic terminals [71] or astrocytes [57], respectively.…”
Section: (D) Cellular and Subcellular Localization Of Cb1r And Its Immentioning
confidence: 86%
“…In agreement, THC produces full tetrad effects in the conditional knockout mice lacking CB1R in GABAergic terminals [102]. Likewise, the GABA-A receptor antagonist bicuculline does not block THCinduced tetrad effects [103]. Interestingly, the effects of cannabinoids on long-term memory and working memory have been associated to CB1R in GABAergic terminals [71] or astrocytes [57], respectively.…”
Section: (D) Cellular and Subcellular Localization Of Cb1r And Its Immentioning
confidence: 86%
“…An imbalance in GABAergic transmission resulting from the chronic caffeine-induced alterations of A 1 and CB 1 levels may have occurred, leading to some adaptive changes in the pyramidal cells and/or in the parvalbumin-expressing (PV) GABAergic neurons, which do not express CB 1 receptors (Katona et al, 1999). Interestingly, the blockade of GABAergic transmission was shown to reverse the cognitive effects of acute THC in vivo (Varvel et al, 2005). A critical imbalance in the temporal coordination of pyramidal cell firing could have become evident when THC was administered, if there was an enhanced sensitivity to the fast spiking activity of PV cells; hence, leading to increased inhibition of pyramidal cell firing.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, a probe trial (60-s duration, no platform present) was given before the first acquisition session and again before the eighth acquisition session. The other training procedures were identical to those previously reported (Varvel et al 2004;Varvel and Lichtman 2002).…”
Section: Methodsmentioning
confidence: 95%