900 MHZ electromagnetic field exposure relieved AD-like symptoms on APP/PS1 mice: A potential non-invasive strategy for AD treatment

Zhi, Wei; Zou, Yong; Ma, Lizhen; He, Shipei; Guo, Zhongzhong; Zhao, Xuelong; Hu, Xiaoyun; Wang, Lifeng

doi:10.1016/j.bbrc.2023.03.083

Cited by 3 publications

(3 citation statements)

References 38 publications

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“…Furthermore, transcranial magnetic stimulation may also alleviate aspects of Alzheimer's Disease (AD) [164]. Further studies in a mouse model of AD reported that exposure to a specific frequency of electromagnetic stimulation led to improved symptoms [165]. It should be noted that these studies were performed against a background of the GMF of Earth.…”

Section: Health Benefits Of Magnetic Fields On the Brainmentioning

confidence: 99%

“…Thus, improvements via exposure to a specific magnetic field appeared to "correct" disease-associated defects in the functionality of the brain. While the molecular mechanisms responsible for the improvements in patients are not known, in the mouse model [165], exposure to the 900 MHZ fields led to decreased amyloid plaque deposition in specific areas of the brain of the mice.…”

Section: Health Benefits Of Magnetic Fields On the Brainmentioning

confidence: 99%

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The Influence of Magnetic Fields, Including the Planetary Magnetic Field, on Complex Life Forms: How Do Biological Systems Function in This Field and in Electromagnetic Fields?

Hart

2024

Biophysica

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Life on Earth evolved to accommodate the biochemical and biophysical boundary conditions of the planet millions of years ago. The former includes nutrients, water, and the ability to synthesize other needed chemicals. The latter includes the 1 g gravity of the planet, radiation, and the geomagnetic field (GMF) of the planet. How complex life forms have accommodated the GMF is not known in detail, considering that Homo sapiens evolved a neurological system, a neuromuscular system, and a cardiovascular system that developed electromagnetic fields as part of their functioning. Therefore, all of these could be impacted by magnetic fields. In addition, many proteins and physiologic processes utilize iron ions, which exhibit magnetic properties. Thus, complex organisms, such as humans, generate magnetic fields, contain significant quantities of iron ions, and respond to exogenous static and electromagnetic fields. Given the current body of literature, it remains somewhat unclear if Homo sapiens use exogenous magnetic fields to regulate function and what can happen if the boundary condition of the GMF no longer exerts an effect. Proposed deep space flights to destinations such as Mars will provide some insights, as space flight could not have been anticipated by evolution. The results of such space flight “experiments” will provide new insights into the role of magnetic fields on human functioning. This review will discuss the literature regarding the involvement of magnetic fields in various normal and disturbed processes in humans while on Earth and then further discuss potential outcomes when the GMF is no longer present to impact host systems, as well as the limitations in the current knowledge. The GMF has been present throughout evolution, but many details of its role in human functioning remain to be elucidated, and how humans have adapted to such fields in order to develop and retain function remains to be elucidated. Why this understudied area has not received the attention required to elucidate the critical information remains a conundrum for both health professionals and those embarking on space flight. However, proposed deep space flights to destinations such as Mars may provide the environments to test and assess the potential roles of magnetic fields in human functioning.

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Section: Health Benefits Of Magnetic Fields On the Brainmentioning

confidence: 99%

Section: Health Benefits Of Magnetic Fields On the Brainmentioning

confidence: 99%

The Influence of Magnetic Fields, Including the Planetary Magnetic Field, on Complex Life Forms: How Do Biological Systems Function in This Field and in Electromagnetic Fields?

Hart

2024

Biophysica

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“…Furthermore, transcranial magnetic stimulation may also alleviate aspects of Alzheimer's Disease (AD) [161]. Further studies in a mouse model of AD reported that exposure to a specific frequency of electromagnetic stimulation led to improved symptoms [162]. It should be noted that these studies were performed against a background of the GMF of Earth.…”

Section: Health Benefits Of Magnetic Fields On the Brainmentioning

confidence: 99%

The Influence of Magnetic Fields including the Geomagnetic Field of Earth on Complex Life Forms: A Silent “Partner” in Human Health and Disease?

Hart

2023

Preprint

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Life on Earth evolved to accommodate the biochemical and biophysical boundary conditions of the planet millions of years ago. The former includes nutrients, water, and ability to synthesize other needed chemicals. The latter include the 1 g gravity of the planet, radiation, and the geomagnetic field (GMF)of the planet. How complex life forms have accommodated the GMF is not known in detail considering that Homo sapiens evolved a neuro system and a cardiovascular system that develops electromagnetic fields as part of their functioning. In addition, many proteins and physiologic processes utilize Fe ions, an ion that exhibits magnetic properties. Thus, complex organisms such as current humans generate magnetic fields, contain significant quantities of the Fe ion, and also respond to exogenous-supplied static and electromagnetic fields. Whether humans can store information in self-generated magnetic fields remains to be determined. Given the current body of literature, it remains somewhat unclear how Homo sapiens use exogenous magnetic fields to regulate function, and what can happen if the boundary condition of the GMF of Earth is no longer exerting an effect. Proposed deep space flights to destinations such as Mars will provide some insights as space flight could not have been anticipated by evolution. The results of such space flight “experiments” will provide new insights in the role of magnetic fields on human functioning. The outcomes may also have implications for those on Earth as magnetic field influences may play a role in developmental conditions such as autism and senescence-associated conditions such as dementia when integration of the biological and biophysical aspects of humans of humans are required for effective functioning. This review will discuss the involvement of magnetic fields on various normal and disturbed processes in humans while on Earth and then further discuss potential outcomes when the GMF is no longer available to impact host systems. Thus, the GMF of the Earth has been present throughout evolution but details of its role in human functions still remain to be elucidated.

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Microwaves activate immune response and promote lymphocytes proliferation of Wistar rats

Ma,

Cao,

Zou

et al. 2024

Preprint

Self Cite

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Objective The potential effects of microwave radiation on human health have been increasingly emphasized with its widespread application in human production and daily life. This study aimed to investigate microwave radiation effects on rat spleen tissue structure and immune function. Methods Male Wistar rats weighed approximately 320 to 350 g were subjected to S band (2.856 GHz) microwave radiation for 20 minutes at an average power density of 50 mW/cm2. At 0 and 7 days after exposure, the concentration of IL-1, IL-1β, IL-2, IL-4, IL-8, IL-10, TNF-α and IFN-γ in rat serum were detected by ELISA. HE staining was used to observe the structure of rat spleen. Western blotting was used to assess the expression of HSP70 and CRT in rat spleen. Additionally, mixed lymphocytes from rat spleens were isolated, and the morphology and proliferation of rat spleen mixed lymphocytes was observed after 24 hours of culture, and their proliferation was evaluated using the CCK-8 assay. Results After exposure to 50 mW/cm2 for 20 minutes, rats showed an increased secretion of inflammatory factors in their serum. This was observed both in the immediately irradiated group (R-0d) and in the irradiated group observed after 7 days (R-7d). The R-0d group exhibited lower levels of IL-1 and IL-8 than the control group (C-0d), while IL-2 and IL-10 secretion was elevated. Conversely, in the R-7d group, levels of IL-1, IL-2, and IL-10 were lower than those in the C-0d group, and IL-8 levels were lower compared to the control group. TNF-α and IFN-γ levels were elevated. Structural examination of rat spleen tissue revealed no significant damage. However, compared to the control group, the irradiated groups (R-0d and R-7d) showed a significant increase and thickening of the white pulp. Additionally, the boundary between the red and white medulla in the R-7d group appeared blurred. Western blotting showed no significant difference in the expression of HSP70 and CRT between the exposed and control groups. In addition, the splenic mixed lymphocytes in the irradiated group showed a significant proliferation of cell colonies. The results of the CCK-8 assay showed that the cell viability and proliferation capacity of the irradiated group were significantly increased compared to the control group. Conclusion The immune system of rats was activated, the pattern of cytokine secretion in rat serum was altered, splenocytes proliferation was promoted, potentially triggering an inflammatory immune response after exposure to 50 mW/cm² of microwave for 20 minutes.

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900 MHZ electromagnetic field exposure relieved AD-like symptoms on APP/PS1 mice: A potential non-invasive strategy for AD treatment

Cited by 3 publications

References 38 publications

The Influence of Magnetic Fields, Including the Planetary Magnetic Field, on Complex Life Forms: How Do Biological Systems Function in This Field and in Electromagnetic Fields?

The Influence of Magnetic Fields, Including the Planetary Magnetic Field, on Complex Life Forms: How Do Biological Systems Function in This Field and in Electromagnetic Fields?

The Influence of Magnetic Fields including the Geomagnetic Field of Earth on Complex Life Forms: A Silent “Partner” in Human Health and Disease?

Microwaves activate immune response and promote lymphocytes proliferation of Wistar rats

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