90K immunostimulatory glycoprotein in children with juvenile idiopathic arthritis

Cecamore, Cristina; Marsili, Manuela; Salvatore, Roberta; Troiani, R; D'Egidio, Maurizia; Tinari, Nicola; Pelliccia, Piernicola; Chiarelli, Francesco; Marcovecchio, Maria Loredana; Breda, Luciana

doi:10.1080/14397595.2017.1397895

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Since Gal-3BP has a scavenger receptor cysteine-rich (SRCR) domain, which is found in innate immunity-related proteins, the role of Gal-3BP has also been extensively studied in relation to immune reactions (20, 21). In line with this, hGal-3BP expression has been reported to be elevated in patients with viral infections or autoimmune diseases (22–26). However, despite the wide range of publications emphasizing its importance, it still remains unknown whether and exactly how Gal-3BP interacts with inflammatory signaling cascades.…”

Section: Introductionmentioning

confidence: 52%

Gal-3BP Negatively Regulates NF-κB Signaling by Inhibiting the Activation of TAK1

et al. 2019

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Galectin-3-binding protein (Gal-3BP) is a member of the family of scavenger receptor cysteine-rich (SRCR) domain-containing proteins, which are associated with the immune system. However, the functional roles and signaling mechanisms of Gal-3BP in host defense and the immune response remain largely unknown. Here, we identified cellular Gal-3BP as a negative regulator of NF-κB activation and proinflammatory cytokine production in lipopolysaccharide (LPS)-stimulated murine embryonic fibroblasts (MEFs). Furthermore, cellular Gal-3BP interacted with transforming growth factor β-activated kinase 1 (TAK1), a crucial mediator of NF-κB activation in response to cellular stress. Gal-3BP inhibited the phosphorylation of TAK1, leading to suppression of its kinase activity and reduced protein stability. In vivo we found that Lgals3BP deficiency in mice enhanced LPS-induced proinflammatory cytokine release and rendered mice more sensitive to LPS-induced endotoxin shock. Overall, these results suggest that Gal-3BP is a novel suppressor of TAK1-dependent NF-κB activation that may have potential in the prevention and treatment of inflammatory diseases.

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Section: Introductionmentioning

confidence: 52%

Gal-3BP Negatively Regulates NF-κB Signaling by Inhibiting the Activation of TAK1

et al. 2019

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“…Gal‐3BP concentration is highly elevated in circulating microparticles of systemic lupus erythematosus patients and the concentration strongly correlates with disease severity . Also, circulating Gal‐3BP concentrations are increased in juvenile idiopathic arthritis patients compared with healthy controls . As explained in detail below, Gal‐3BP expression and secretion are also significantly up‐regulated in various microbial infections indicating a role in innate immunity against viral and bacterial infections.…”

Section: Expression Pattern Of Gal‐3bpmentioning

confidence: 94%

“…46 Also, circulating Gal-3BP concentrations are increased in juvenile idiopathic arthritis patients compared with healthy controls. 47 As explained in detail below, Gal-3BP expression and secretion are also significantly up-regulated in various microbial infections indicating a role in innate immunity against viral and bacterial infections.…”

Section: Microbial Proteinsmentioning

confidence: 96%

Galectin-3-binding protein: A multitask glycoprotein with innate immunity functions in viral and bacterial infections

Loimaranta

Hepojoki

Laaksoaho

et al. 2018

Journal of Leukocyte Biology

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Galectin-3-binding protein (Gal-3BP) is a ubiquitous and multifunctional secreted glycoprotein originally identified and mainly studied in the context of neoplastic transformation and cancer progression. However, Gal-3BP expression is induced in viral infection and by a multitude of molecules that either mimic or are characteristic for an ongoing inflammation and microbial infection, such as IFN-α, IFN-β, IFN-γ, TNF-α, poly(I:C), dsRNA, and dsDNA. Furthermore, Gal-3BP belongs to the scavenger receptor cysteine-rich (SRCR) domain-containing protein family, by virtue of its N-terminal SRCR domain. The SRCR domain is found in soluble or membrane-associated innate immunity-related proteins and is implicated in self-nonself discrimination. This review summarizes the current knowledge of structural features of Gal-3BP and its proposed intracellular and extracellular innate immunity functions with special emphasis on viral and bacterial infections.

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“…A multitude of epidemiological and clinical studies have documented that patients affected by pathological conditions such as cancer, viral infections, and autoimmune disorders frequently display supranormal levels of Gal-3BP [22][23][24][25][26][27], which are associated with unfavorable clinical outcomes [5,[28][29][30][31][32][33][34]. On the contrary, low levels of Gal-3BP have been found to be associated with an augmented response to antiviral therapies [35].…”

Section: Introductionmentioning

confidence: 99%

Gal-3BP in Viral Infections: An Emerging Role in Severe Acute Respiratory Syndrome Coronavirus 2

Gallo

Arienzo

Iacobelli³

et al. 2022

IJMS

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Galectin-3 binding protein (Gal-3BP) is a multifunctional glycoprotein involved in cell–cell and cell–matrix interactions known to be upregulated in cancer and various viral infections, including HIV-1, HCV, and SARS-CoV-2, with a key role in regulating the antiviral immune response. Studies have identified a direct correlation between circulating levels of Gal-3BP and the severity of disease and/or disease progression for some viral infections, including SARS-CoV-2, suggesting a role of Gal-3BP in these processes. Due to Gal-3BP’s complex biology, the molecular mechanisms underlying its role in viral diseases have been only partially clarified. Gal-3BP induces the expression of interferons (IFNs) and proinflammatory cytokines, including interleukin-6 (IL-6), mainly interacting with galectin-3, targeting the TNF receptor-associated factors (TRAF-6 and TRAF-3) complex, thus having a putative role in the modulation of TGF-β signaling. In addition, an antiviral activity of Gal-3BP has been ascribed to a direct interaction of the protein with virus components. In this review, we explored the role of Gal-3BP in viral infections and the relationship between Gal-3BP upregulation and disease severity and progression, mainly focusing on SARS-CoV-2. Augmented knowledge of Gal-3BP’s role in virus infections can be useful to evaluate its possible use as a prognostic biomarker and as a putative target to block or attenuate severe disease.

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90K immunostimulatory glycoprotein in children with juvenile idiopathic arthritis

Abstract: Our study showed that 90K glycoprotein levels are increased in JIA children compared to healthy controls, suggesting a potential pathogenetic role in the JIA. Besides, 12 months of therapy with etanercept can reduce 90K levels.

Cited by 4 publications

References 19 publications

Gal-3BP Negatively Regulates NF-κB Signaling by Inhibiting the Activation of TAK1

Gal-3BP Negatively Regulates NF-κB Signaling by Inhibiting the Activation of TAK1

Galectin-3-binding protein: A multitask glycoprotein with innate immunity functions in viral and bacterial infections

Gal-3BP in Viral Infections: An Emerging Role in Severe Acute Respiratory Syndrome Coronavirus 2

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