91166185 The ultrastructure of mast cells in the uterus throughout the normal menstrual cycle and the postmenopause

Drudy, L.; Sheppard, B. L.; Bonnar, J.

doi:10.1016/0378-5122(91)90169-q

Cited by 12 publications

(18 citation statements)

References 10 publications

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“…In the case of M. domestica, uterine mast cells stained only with Alcian blue, while macrophages stained only PAS positive. The ultrastructural pictures of mast cell granules revealed different electron density but no crystalline or scroll-like pattern as found in human mast cells [Drudy et al, 1991]. The same holds true for other descriptions of mast cells in marsupials as reported by Haynes [1991], Santos and Machado [1994] and Chiarini-Garcia and Pereira [1999].…”

Section: Discussionsupporting

confidence: 68%

“…It is not the number of mast cells that varies, but the number and variety of granules within mast cells that differ according to the stage of the cycle [Drudy et al, 1991].…”

Section: Discussionmentioning

confidence: 99%

“…Brandon and Evans [1983] gave a numerical account of uterine macrophages in the hamster and Drudy et al [1991] for the human uterus.…”

Section: Discussionmentioning

confidence: 99%

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Ultrastructural Changes in the Uterine Luminal and Glandular Epithelium during the Oestrous Cycle of the Marsupial Monodelphis domestica (Grey Short-Tailed Opossum)

Wick

Kress²

2001

Cells Tissues Organs

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Ultrastructural changes in the endometrium associated with the oestrous cycle were studied in the South American marsupial Monodelphis domestica. The most conspicuous changes include the height and the differentiation of the uterine luminal and glandular epithelium, which consists of ciliated and non-ciliated cells. The glandular epithelium attains its maximum development during oestrus, the luminal epithelium at postoestrus. A distinct increase in the number of ciliated cells can be observed during pro-oestrus, reaching a maximum number at oestrus; this is followed by a process of deciliation. The presence of solitary cilia on the apices of non-ciliated cells is very conspicuous during all oestrous stages and can best be seen on the luminal epithelium. These findings differ from the observations in eutherian mammals, where solitary cilia are only found in the immature uterus or after ovariectomy. The secretory activity of non-ciliated cells of the luminal epithelium is hardly noticeable along the apical membrane and stains only very faintly with Alcian blue. The glandular epithelium cells are filled apically with exocytotic vesicles at oestrus and early postoestrus. However, in contrast to the cervical gland cells, they hardly stain with Alcian blue, indicating that mucins of a different type must be present. Mechanisms for the remodelling of the luminal and glandular epithelium are especially conspicuous at metoestrus and early pro-oestrus and include the presence of autolysosomes, residual bodies and apoptotic bodies. In the endometrial stroma, around the uterine glands, macrophages accumulate and attain a typical oestrous stage-dependent appearance during their phagocytotic activities.

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Section: Discussionsupporting

confidence: 68%

“…It is not the number of mast cells that varies, but the number and variety of granules within mast cells that differ according to the stage of the cycle [Drudy et al, 1991].…”

Section: Discussionmentioning

confidence: 99%

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Ultrastructural Changes in the Uterine Luminal and Glandular Epithelium during the Oestrous Cycle of the Marsupial Monodelphis domestica (Grey Short-Tailed Opossum)

Wick

Kress²

2001

Cells Tissues Organs

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“…The ultrastructural pictures of mast cell granules showed different electron density but no crystalline or scroll-like pattern as found in human mast cells [Drudy et al, 1991]. The same holds true for the other mast cell descriptions of marsupials, as reported by Haynes [1991], Santos and Machado [1994], and Chiarini-Garcia and Pereira [1999].…”

Section: Discussionsupporting

confidence: 67%

Ultrastructural Changes in the Cervical Epithelium during the Estrous Cycle of the Marsupial Monodelphis domestica (Grey Short-Tailed Opossum)

Wick

Kress²

2002

Cells Tissues Organs

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Ultrastructural changes in the cervical epithelium related to the estrous cycle have been studied in the South American marsupial Monodelphis domestica. The two cervices protrude with prominent papillae into the sinus vaginalis. At times of simple columnar at others of more pseudostratified character consists of two types of cells, ciliated and secretory cells. The mucosal epithelium is uniform in its entire length and shows no division into an endo- and ectocervix. The mucosa of the cervix differs from the uterine endometrium. There are no glandular structures, but the luminal epithelium shows deep invaginations underlined by dense connective tissue. The most conspicuous changes include the height and the differentiation of the cervical epithelium which attains its maximum development during estrus, where secretory cells are fully packed with large secretory granules and ciliated cells are well developed. After extruding their granules, secretory cells may transform into ciliated cells, while ciliated cells show the phenomenon of deciliation in which cilia packets are shed into the cervical lumen. This transformation process takes place mainly during post- and metestrus. The presence of solitary cilia is only noticeable during pro-estrus, being in contrast to the uterine epithelium where they appear during the whole estrous cycle.

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“…Recently the functional roles of these latter "inflammatory" cells in remodeling processes during the normal menstrual cycle have been receiving attention [3]. The MC in particular has been the subject of several histological reports [4][5][6][7][8][9], and MC numbers have been related to various clinical conditions [10][11][12]. The MC is now considered to play a pivotal role in a variety of biological responses including angiogenesis, fibrosis, wound healing, inflammation, and tissue remodeling [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Mast Cell and Eosinophil Distribution and Activation in Human Endometrium throughout the Menstrual Cycle1

Jeziorska¹,

Salamonsen

Woolley³

1995

Biology of Reproduction

139

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Tryptase and chymase immunolocalization techniques have been used to examine the distribution, activation, and tryptase/chymase phenotype of mast cells (MCs) in 107 endometrial specimens that represented every day of the human menstrual cycle. MCs were identified in the endometrium in all stages of the menstrual cycle; similar MC numbers were observed for the functionalis, basalis, and muscularis. Extensive MC activation/degranulation, as judged by extracellular tryptase, was a common feature of the functionalis in specimens sampled just prior to and during menstruation. MC activation was also prominent in the functionalis at times coincident with recognized stromal edema. MCs of the functionalis did not contain chymase; all stained for tryptase and represent the MCT phenotype. By contrast, the basalis and muscularis showed a proportion of MCs containing both tryptase and chymase, MCTC. One important function for extracellular MC tryptase and chymase is their ability to activate precursor forms of the matrix metalloproteinases, enzymes recognized as instrumental in stromal degradation. Quantitative analysis of MC numbers, expressed relative to stromal cell numbers/mm2, indicated no major changes during the menstrual cycle, although changes in MC morphology, granule content, and activation/degranulation were recognized for specific stages. Eosinophils, detected with monoclonal antibodies EG1 and EG2, were absent from extravascular sites between Days 5 and 26 but showed local accumulations just prior to and during menstruation. Since MCs and eosinophils between them contain a variety of potent mediators, it seems likely that both cell types assume important functional roles in relation to tissue and vascular remodeling associated with endometrial physiology.

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91166185 The ultrastructure of mast cells in the uterus throughout the normal menstrual cycle and the postmenopause

Cited by 12 publications

References 10 publications

Ultrastructural Changes in the Uterine Luminal and Glandular Epithelium during the Oestrous Cycle of the Marsupial <i>Monodelphis domestica</i> (Grey Short-Tailed Opossum)

Ultrastructural Changes in the Uterine Luminal and Glandular Epithelium during the Oestrous Cycle of the Marsupial <i>Monodelphis domestica</i> (Grey Short-Tailed Opossum)

Ultrastructural Changes in the Cervical Epithelium during the Estrous Cycle of the Marsupial <i>Monodelphis domestica</i> (Grey Short-Tailed Opossum)

Mast Cell and Eosinophil Distribution and Activation in Human Endometrium throughout the Menstrual Cycle1

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