912: Fluorescence Detection with 5-Aminolevulinic Acid (ALA) Reduces the Risk of Tumor Recurrence and Progression in Patients with Superficial Bladder Cancer: 5 Year Results of a Prospective Randomized Trial

Surveillance for Recurrent Bladder Cancer Using a Point-of-Care Proteomic Assay

“…17 Other studies have found similar or higher incidences of occult cancers. [23][24][25][26][27][28] The combination of cystoscopy with the point-of-care NMP22 assay in this investigation increased detection of bladder cancer recurrences to 99.0%, compared with 91.3% for cystoscopy alone.…”

The management of superficial transitional cell carcinoma of the bladder: a critical assessment of contemporary concepts and future perspectives

“…Studying the quality of both approaches, Daniltschenko et al [39] randomized 115 patients with bladder tumours either to white light or fluorescence‐guided TURBT; 6–8 weeks later a routine re‐TURBT showed residual tumour in 41% for the white‐light and only 16% for the ALA group. The 5‐year follow‐up data from this study are available and showed a difference in recurrence at 12 months of 18%, and after 3 years of 14% ( P < 0.0046) [40]. In the ongoing discussion the advantage of the fluorescence‐assisted TURBT for superficial papillary lesions has not yet been confirmed.…”

Correct answers to multiple choice questions appearing in the European Urology Update Series 2005

“…Despite this advantage in most studies more (and not less) tissue is removed with fluorescence‐guided TURBT, because the urologist also removes tissue with no malignant potential but which is fluorescent. No studies reported an advantage for exophytic lesions [17–20].…”

“…c. Video-urodynamics is the standard for assessing persistent urinary incontinence after prostatectomy [15][16][17]; it is not indicated in the initial management of female urinary incontinence [1] and the examinations must be repeated several times to obtain reproducibility [18]. Certainly it provides radiographs at appropriate functional moments [19].…”

“…Despite this advantage in most studies more (and not less) tissue is removed with fluorescence-guided TURBT, because the urologist also removes tissue with no malignant potential but which is fluorescent. No studies reported an advantage for exophytic lesions [17][18][19][20]. 6. d. One immediate instillation is given in all trials via a transurethral catheter within 6-24 h after the initial TURBT.…”