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Abstract

INTRODUCTION: Many Pharmacologically active compounds are amphiphilic in nature, which may undergo different types of association, and whose site of action is frequently, the Plasma membrane. In many cases excellent correlation between surface activity of drugs and their biological actions was demonstrated 1-12. Earlier reports show that the wide variety of drugs acts by common mechanism i.e. due to their surface activity, which governs their action 13-20. It has been shown that the surface-active drugs at the site of their action generate liquid membranes, which act as barrier to the transport of essential permeants.