928: Predicting Response to Dexmedetomidine in Mechanically Ventilated Intensive Care Unit Patients

Gbadamosi, Sheriff; Morton, James; Peters, Nicholas A.

doi:10.1097/01.ccm.0000633248.30531.23

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“…Dexmedetomidine is a highly selective agonist for the α2-adrenoreceptor that has sedative, anxiolytic, and analgesic properties without respiratory suppression (3,4). Its shorter duration of action (half-life of plasma ~ 2-3 hours) compared to clonidine and its anesthetic maintaining effect have led to the use of dexmedetomidine as an adjuvant in general anesthesia (5). Dexmedetomidine is currently widely used as an adjuvant for intravenous propofol-based intravenous anesthesia (6,7).…”

Section: Introductionmentioning

confidence: 99%

A comparative study on the effect of infusion of 0.3 and 0.6 μg / kg dexmedetomidine during surgery on changes in hemodynamic parameters and pain in patients undergoing spinal surgery under general anesthesia: A 3-blind clinical trial

Masoudifar¹,

Hashemi²,

Rahimian³

2021

PJMHS

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Introduction: Dexmedetomidine is a drug used widely in recent years to reduce complications during and after surgery, but there is a disagreement about the optimal dose of this drug. The aim of present study was to compare the effects of infusion of two doses of 0.3 and 0.6 μg / kg dexmedetomidine during surgery on changes in hemodynamic parameters and pain in patients undergoing spinal surgery under general anesthesia. Methods: In a clinical trial study, 81 patients, who were candidates for spinal surgery, were randomly assigned to three groups (27 patients in each group). The first group received 0.3 μg / kg dexmedetomidine and the second group received 0.6 μg / kg dexmedetomidine intravenously and the third group (control) received normal saline. Hemodynamic parameters during surgery and recovery and postoperative stage complications such as pain severity and the first time of receiving opioids were evaluated and compared in three groups. Results: Patients who received 0.6 μg / kg dexmedetomidine had lower blood pressure, lower heart rate and lower oxygen saturation during surgery. Also, the severity of postoperative pain was lower in this group. However, the first time of receiving opioid, received drug, length of stay in recovery and extubation time were not significantly different among the three groups. Conclusion: The use of 6 μg / kg dexmedetomidine intravenously is associated with reduced postoperative pain and appropriate hemodynamic stability during surgery. Therefore, it seems that this dose of drug to be effective in preventing acute postoperative pain. Keywords: Postoperative pain, Hemodynamics, Dexmedetomidine

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Section: Introductionmentioning

confidence: 99%