Regular and Young Investigator Award Abstracts 2021
DOI: 10.1136/jitc-2021-sitc2021.942
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942 The tumor microbiome correlates with response to immune checkpoint inhibitors in renal cell carcinoma

Abstract: BackgroundImmune checkpoint inhibitor therapy, or ICI, is currently the most successful treatment option for patients with renal cell carcinoma (RCC). However, only 20% of patients have a durable response,1 driving a significant need to improve treatment outcomes. The tumor microbiome has recently been shown to play a role in chemotherapy-based treatment outcomes, but, to our knowledge, no study has explored its role in response to ICIs.2–4MethodsTumor samples were collected from 22 patients with RCC as a part… Show more

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Cited by 3 publications
(3 citation statements)
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“…Our study encompassed thus far the largest number of ccRCC cases subject to ITB detection. In comparison to previous smaller studies 1417 , several ITB features appeared to be ubiquitously present at high relative abundance including Proteobacteria and Firmicutes at phylum level and Pseudomonas , Acinetobacter and Staphylococcus at genus level. Lack of difference in ITB loads, composition or diversity between normal and cancer tissue was one of our major findings.…”
Section: Discussioncontrasting
confidence: 91%
See 1 more Smart Citation
“…Our study encompassed thus far the largest number of ccRCC cases subject to ITB detection. In comparison to previous smaller studies 1417 , several ITB features appeared to be ubiquitously present at high relative abundance including Proteobacteria and Firmicutes at phylum level and Pseudomonas , Acinetobacter and Staphylococcus at genus level. Lack of difference in ITB loads, composition or diversity between normal and cancer tissue was one of our major findings.…”
Section: Discussioncontrasting
confidence: 91%
“…Clear-cell renal cell carcinoma (ccRCC) is the most common type of malignancy in kidney that is conventionally accepted as sterile organ and ccRCC is expected to harbor a low biomass of ITB. To date, the existing literature on ITB in ccRCC is limited to three full papers [14][15][16] and one meeting proceeding 17 . These studies suffer from small sample sizes, lack of racial diversity, use of a single sequencing technology, and inadequate decontamination process.…”
Section: Introductionmentioning
confidence: 99%
“…On the other hand, tumors in patients who did not respond to checkpoint inhibitor therapy exhibited enrichment of species including Candidatus Promineofilum breve , Clostridioides difficile, Nocardia cyriacigeorgica, Streptomyces sp. CdTB01 , and Streptomyces venezuelae [ 31 ]. Based on these results, it can be speculated that the composition of the tumor microbiome may predict the effectiveness of therapeutic responses, alongside currently used markers.…”
Section: Role Of Antibioticsmentioning
confidence: 99%