946 Long-Term Outcome of Renal Function in Bladder Cancer Patients After Radical Cystectomy

Osawa, Takahiro; Maruyama, Satoru; Abe, Takashige; Maru, Shintaro; Aoyagi, Toshiki; Sazawa, Ataru; Shinohara, Nobuo; Nonomura, Katsuya

doi:10.1016/j.juro.2010.02.1825

Cited by 20 publications

(45 citation statements)

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“…In all, six articles were included for analysing the effect of UD on RFn . Articles from same the centres were excluded if they had duplicate data or described different outcomes .…”

Section: Resultsmentioning

confidence: 99%

“…Osawa et al. reported a 15% decline in the median eGFR, while Jin et al. reported only a 3% decline ( P values were not calculated).…”

Section: What Is the Effect Of Obs On Long‐term Rfn?mentioning

confidence: 97%

“…In addition, the authors defined chronic UTI as bacteriuria ≥10 5 colony‐forming units (CFU)/mL lasting for ≥3 months in a year, while acute pyelonephritis was defined according to Osawa et al. as bacteriuria >10 5 CFU/mL with the presence of flank pain/tenderness and fever (>38 °C axillary). In another publication, the authors defined UTI as >10 4 CFU/mL with suprapubic pain or >10 5 CFU/mL with or without symptoms and urosepsis when associated with positive blood culture .…”

Section: What Is the Effect Of Obs On Long‐term Rfn?mentioning

confidence: 99%

“… used the Modification of Diet in Renal Disease equation (MDRD), while Osawa et al. used the standard Japanese formula for eGFR: (eGFR = 194 × age −0.287 × SCr −1.094 mL/min/1.73m 2 × [0.739 if female]).…”

Section: What Is the Effect Of Obs On Long‐term Rfn?mentioning

confidence: 99%

“…The event of RFn deterioration showed marked heterogeneity across studies; Osawa et al. used a 25% decline in eGFR from baseline as a sign of RFn deterioration. On the other hand, Jin et al.…”

Section: What Is the Effect Of Obs On Long‐term Rfn?mentioning

confidence: 99%

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Renal function evaluation in patients undergoing orthotopic bladder substitution: a systematic review of literature

et al. 2014

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Renal function (RFn) after orthotopic bladder substitution (OBS) is a critical point to be assessed. We performed a systematic review of MEDLINE for full length peer reviewed English articles from the year 2000 till January 2013. We included only original articles and excluded reviews, editorials and replies and abstracts presented in conferences. The outcome is formulated in research questions; what is the status of RFn after OBS? Which is better, the direct free-refluxing or anti-refluxing ureteroileal anastomosis (UIA) techniques? Studies reporting RFn as secondary outcome were also reported. A total of 129 publications were reviewed for full text and only 41 were included in this review. All studies were of low level of evidence and grade of recommendations. Only 3 randomized controlled trials were included and were of poor quality. Renal function after OBS was poorly described in the literature with no universal definition about RFn deterioration or outcome with no consensus on the best evaluation method. Urinary obstruction, chemotherapy and pyelonephritis appeared significant factors but with insufficient evidence. There is a universal trend to use the free refluxing technique for UIA to avoid complications of anti-refluxing techniques. However, the anti-reflux technique proved acceptable outcome in experienced hands. There is marked heterogeneity and underestimation of RFn evaluation among reported outcomes after OBS with most publications reporting the incidence of UIA and pyelonephritis with paucity reporting absolute figures about RFn measurements. In conclusion, urinary tract obstruction remains the main factor of RFn deterioration after OBS. Methods evaluating RFn, definitions of RFn outcome and factors predicting it are poorly studied in the literature and the current evidence is relatively weak to draw solid conclusions. Further well-designed studies and consensus about method of assessment and definitions of RFn are warranted.

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“…In all, six articles were included for analysing the effect of UD on RFn . Articles from same the centres were excluded if they had duplicate data or described different outcomes .…”

Section: Resultsmentioning

confidence: 99%

“…Osawa et al. reported a 15% decline in the median eGFR, while Jin et al. reported only a 3% decline ( P values were not calculated).…”

Section: What Is the Effect Of Obs On Long‐term Rfn?mentioning

confidence: 97%

Section: What Is the Effect Of Obs On Long‐term Rfn?mentioning

confidence: 99%

Section: What Is the Effect Of Obs On Long‐term Rfn?mentioning

confidence: 99%

Section: What Is the Effect Of Obs On Long‐term Rfn?mentioning

confidence: 99%

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