967 The CB1 Receptor Antagonist Rimonabant Suppresses Gastric Interdigestive Motility and Hunger Pangs in Healthy Volunteers

Kindt, Sébastien; Vos, Rita; Scarpellini, Emidio; Janssen, Pieter; Berghe, Pieter Vanden; Tack, Jan

doi:10.1016/s0016-5085(10)60651-8

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“…After Roux‐en‐Y gastric bypass surgery, motilin, but not ghrelin plasma levels decreased in parallel with lower hedonic hunger scores 50 . In a preliminary report, endocannabinoid type 1 receptor antagonist rimonabant was also found to inhibit gastric phase III and the associated hunger peaks 51 …”

Section: Gastrointestinal Signals Involved In Determining the Return Of Hungermentioning

confidence: 96%

“…50 In a preliminary report, endocannabinoid type 1 receptor antagonist rimonabant was also found to inhibit gastric phase III and the associated hunger peaks. 51 The mechanisms controlling the release of motilin from duodenal entero-endocrine cells in health and disease are poorly understood and need to be studied in further detail. Fasting antral contractility episodes (MMCs) are reduced to zero over a period of 4 h after GLP-1 infusion in healthy volunteers.…”

Section: Motilin-induced Gastric Phase III As a Determinant Of The Return Of Hunger After A Mealmentioning

confidence: 99%

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The gastrointestinal tract in hunger and satiety signalling

et al. 2021

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Background: Different peripheral pathways are implicated in the regulation of the food ingestion-digestion cycle.Methods: Narrative review on gastrointestinal mechanisms involved in satiety and hunger signalling.Results: Combined mechano-and chemoreceptors, peripherally released peptide hormones and neural pathways provide feedback to the brain to determine sensations of hunger (increase energy intake) or satiation (cessation of energy intake) and regulate the human metabolism. The gastric accommodation reflex, which consists of a transient relaxation of the proximal stomach during food intake, has been identified as a major determinant of meal volume, through activation of tension-sensitive gastric mechanoreceptors. Motilin, whose release is the trigger of gastric Phase 3, has been identified as the major determinant of return of hunger after a meal. In addition, the release of several peptide hormones such as glucagonlike peptide 1 (GLP-1), cholecystokinin as well as motilin and ghrelin contributes to gut-brain signalling with relevance to control of hunger and satiety. A number of nutrients, such as bitter tastants, as well as pharmacological agents, such as endocannabinoid receptor antagonists and GLP-1 analogues act on these pathways to influence hunger, satiation and food intake. Conclusion:Gastrointestinal mechanisms such as gastric accommodation and motilin release are key determinants of satiety and hunger.

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Section: Gastrointestinal Signals Involved In Determining the Return Of Hungermentioning

confidence: 96%

Section: Motilin-induced Gastric Phase III As a Determinant Of The Return Of Hunger After A Mealmentioning

confidence: 99%