969 11c-Acetate Pet/Ct Imaging of Prostate Cancer: Detection of Recurrent Disease in Patients With Psa Relapse Following Radical Prostatectomy or Radiotherapy

Müller-Mattheis, V.; Fahlbusch, M.; Hautzel, Hubertus; Albers, Peter

doi:10.1016/s1569-9056(11)60951-2

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“…In another study, Müller‐Mattheis et al. reported three out of seven positive lymph nodes as false positive results.…”

Section: Discussionmentioning

confidence: 94%

“…The remaining 66 citations were evaluated in more detail; 42 studies were excluded at this stage for being letters to editors, case reports, narrative review articles, or due to incomplete data. Finally, 24 studies were included in the systematic review . Table shows the characteristics of included studies .…”

Section: Resultsmentioning

confidence: 99%

“…In all, 14 studies reported accuracy of 11 C‐acetate PET imaging for evaluation of recurrence in patients with evidence of PSA relapse (either after surgery or after radiotherapy, RT) . Figure shows the forest plots of sensitivity and specificity pooling.…”

Section: Resultsmentioning

confidence: 99%

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Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

et al. 2013

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• To review the literature on the application of 11 C-acetate positron-emission tomography (PET) imaging in prostate cancer.• We systematically reviewed the available literature and presented the results in meta-analysis format.• PubMed, SCOPUS, ISI web of knowledge, Science Direct, Springer, and Google Scholar were searched with 'Acetate AND PET AND Prostate' as keywords.• All studies that evaluated accuracy of 11 C-acetate imaging in primary or recurrent prostate cancer were included, if enough data could be extracted for calculation of sensitivity and/or specificity.• In all, 23 studies were included in the study. For evaluation of primary tumour, pooled sensitivity was 75.1 (69.8-79.8)% and specificity was 75.8 (72.4-78.9)%. • For detection of recurrence, sensitivity was 64 (59-69)% and specificity was 93 (83-98)%. Sensitivity for recurrence detection was higher in post-surgical vs post-radiotherapy patients and in patients with PSA at relapse of >1 ng/mL. • Studies using PET/computed tomography vs PET also showed higher sensitivity for detection of recurrence.• Imaging with 11 C-acetate PET can be useful in patients with prostate cancer. This is especially true for evaluation of patients at PSA relapse, although the sensitivity is overall low.• For primary tumour evaluation (localisation of tumour in the prostate and differentiation of malignant from benign lesions), 11 C-acetate is of limited value due to low sensitivity and specificity.• Due to the poor quality of the included studies, the results should be interpreted with caution and further high-quality studies are needed.

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“…In another study, Müller‐Mattheis et al. reported three out of seven positive lymph nodes as false positive results.…”

Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

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Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

et al. 2013

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969 11c-Acetate Pet/Ct Imaging of Prostate Cancer: Detection of Recurrent Disease in Patients With Psa Relapse Following Radical Prostatectomy or Radiotherapy

Cited by 1 publication

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Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

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969 11c-Acetate Pet/Ct Imaging of Prostate Cancer: Detection of Recurrent Disease in Patients With Psa Relapse Following Radical Prostatectomy or Radiotherapy

Cited by 1 publication

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Application of 11C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

Application of 11C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

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Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature

Application of ¹¹C‐acetate positron‐emission tomography (PET) imaging in prostate cancer: systematic review and meta‐analysis of the literature