980: Evaluation of Guanfacine Use, Safety, and Efficacy for Management of Agitation

Abstract

INTRODUCTION: Guanfacine (Tenex) is an alpha-2 agonist. Immediate release guanfacine has an indication for hypertension and extended release is labeled for use in Attention Deficit Hyperactivity Disorder. Recent case reports suggest a possible role in delirium and alcohol withdrawal. At Tampa General Hospital, guanfacine was added to the medication formulary for the management of ICU delirium. This medication use evaluation assessed the use of guanfacine and its associated safety and efficacy for this indication.

Effect of Enteral Guanfacine on Dexmedetomidine Use in the ICU

“…Guanfacine, another enteral alpha-2 agonist, may be an alternative to clonidine with less cardiovascular adverse effects (13)(14)(15)(16). Currently, data regarding the use of guanfacine for this indication are limited to published abstracts (14)(15)(16).…”

“…However, use of clonidine maybe limited by hypotension with rates reported as high as 44% when used for dexmedetomidine weaning (10)(11)(12). Guanfacine, another enteral alpha-2 agonist, may be an alternative to clonidine with less cardiovascular adverse effects (13)(14)(15)(16). Currently, data regarding the use of guanfacine for this indication are limited to published abstracts (14)(15)(16).…”