Sotos syndrome is a growth regulation disorder. Accessory conduction pathways, the anatomical structures responsible for Wolff-Parkinson-White syndrome, are thought to result from developmental failure to eradicate the remnants of the atrioventricular connections during cardiogenesis. Although the reported prevalence of congenital heart disease in Sotos syndrome is 10 times higher than in the general population, there are no reported cases with ventricular pre-excitation. We report a patient with Sotos syndrome with two distinct accessory atrioventricular bypass tracts documented by invasive electrophysiology testing and a curative catheter ablation procedure.