99m'Tc-HEXAMETHYLPROPYLENEAMINE OXIME SCANS TO CONFIRM BRAIN DEATH

Roine, R.O.; Launes, Jyrki; Lindroth, L.; Nikkinen, Päivi

doi:10.1016/s0140-6736(86)92237-3

Cited by 22 publications

(10 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…28 Functional imaging using cerebral perfusion tracers and single photon emission computed tomography [29][30][31][32][33][34] or cerebral metabolism tracers and PET 35 typically show an "hollow skull phenomenon" in brain death patients, confirming the absence of neuronal function in the whole brain ( figure 3). …”

Section: Brain Deathmentioning

confidence: 99%

Brain function in coma, vegetative state, and related disorders

Laureys

Owen

Schiff

2004

The Lancet Neurology

894

562

View full text Add to dashboard Cite

We review the nosological criteria and functional neuroanatomical basis for brain death, coma, vegetative state, minimally conscious state and the locked-in state. Functional neuroimaging is providing new insights into cerebral activity in patients with severe brain damage. Measurements of cerebral metabolism and brain activations in response to sensory stimuli using positron emission tomography (PET), functional magnetic resonance imaging (fMRI) and electrophysiological methods have significant potential to provide unique windows on to the presence, degree and location of any residual brain function. However, use of these techniques in severely brain-damaged persons is methodologically complex and requires careful quantitative analysis and interpretation. In addition, ethical frameworks to guide research in these patient populations must be further developed. At present, nosological distinctions confirmed by clinical examinations remain the standard for accurate diagnosis and prognosis. Neuroimaging techniques, while extremely promising, remain important tools for clinical research that should ultimately extend our understanding of the underlying mechanisms of these disorders.3

show abstract

Section: Brain Deathmentioning

confidence: 99%

Brain function in coma, vegetative state, and related disorders

Laureys

Owen

Schiff

2004

The Lancet Neurology

894

562

View full text Add to dashboard Cite

show abstract

“…Following an intravenous bolus injection of the tracer, the absent uptake of the tracer into the intracranial cavity confirms the loss of cerebral perfusion [15,16,22,25,26]. This method can be performed at the bedside and therefore does not carry the risks of transportation away from the intensive care unit.…”

Section: Scintigraphymentioning

confidence: 99%

European brain death codes: a comparison of national guidelines

Haupt

Rudolf

1999

Journal of Neurology

166

View full text Add to dashboard Cite

The majority of European countries have published recommendations for the diagnosis of brain death as a necessary prerequisite for organ donation. The concept of brain death as defining the death of the individual is accepted in all European countries; however, the guidelines for determining the total and irreversible loss of all brain functions differ somewhat in the various countries. While the clinical examination and documentation of the clinical signs of brain death are very uniform, there are significant differences in the guidelines for using technical confirmatory tests to corroborate the clinical signs. These range from rejecting all technical tests to accepting of multiple neurophysiological tests alone or in combination. The present study examined the similarities and differences in current concepts of brain death in the various European countries and their recommendations for the diagnosis of brain death. The diagnosis of brain death is based on a number of prerequisites, on the clinical diagnosis of deep coma, loss of all brainstem reflexes, and the demonstration of apnea. Neurophysiological tests are recommended by a number of national professional societies as confirmatory tests to confirm the clinical diagnosis of brain death and shorten otherwise necessary waiting periods of 6-12 h. Most brain death codes allow the use of electroencephalography, which must demonstrate electrocortical silence over a certain period. Evoked cerebral potentials can demonstrate the successive loss of activity of various afferent pathways and are accepted in some countries as a confirmatory test. Other neurophysiological tests which demonstrate the loss of cerebral perfusion can be implemented. Brain scintigraphy can confirm the loss of isotope uptake into the brain. Doppler sonography also demonstrates cessation of brain perfusion. Cerebral panangiography may also be used to demonstrate the loss of brain perfusion but is less desirable since it might endanger the patient.

show abstract

“…SPECT investigations can be performed in the Nuclear Medicine Department only. Among all the studies published on the role of HMPAO-SPECT for the diagnosis of brain death [17,26,[31][32][33][34][35][36][37], only a few are systematic or based on a large population. SPECT images are believed to be superior in the evaluation of the posterior fossa.…”

mentioning

confidence: 99%

Tc-99m-hmpa0 single photon emission computed tomography (SPECT) as an ancillary test in the diagnosis of brain death

Keske

1998

Intensive Care Med

View full text Add to dashboard Cite

99m'Tc-HEXAMETHYLPROPYLENEAMINE OXIME SCANS TO CONFIRM BRAIN DEATH

Cited by 22 publications

References 2 publications

Brain function in coma, vegetative state, and related disorders

Brain function in coma, vegetative state, and related disorders

European brain death codes: a comparison of national guidelines

Tc-99m-hmpa0 single photon emission computed tomography (SPECT) as an ancillary test in the diagnosis of brain death

Contact Info

Product

Resources

About