99mTc-DTPA volume of distribution, half-life and glomerular filtration rate in normal adults

Holness, Jennifer L; Fleming, John; Malaroda, Alessandra; Warwick, James

doi:10.1097/mnm.0b013e328364aa12

Cited by 12 publications

(11 citation statements)

References 31 publications

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“…QC on the basis of physiologic metrics is difficult in a heterogenous clinic such of ours, consisting of patient populations ranging from healthy, potential kidney donors to patients with severe renal dysfunction. As an example, errors between volume of distribution estimated using BSA and Brochner–Mortensen corrected GFR and BSA alone have been proposed for QC 23, but had 24.0% variability, which is too large to be of clinical utility as a QC measure 14. This conclusion is consistent with those of McMeekin et al .…”

Section: Discussionsupporting

confidence: 82%

“…Other physiologic parameters could be considered for QC testing, including volume of distribution, extra-cellular volume, and time to 50% washout ( T 1/2 ) 4,23. We did not include these error measures as variabilities, even in normal populations of potential donors, were relatively high compared with the physics-based quality metrics described in this work, and certainly were outside of ‘normal’ values in patients with renal disease.…”

Section: Discussionmentioning

confidence: 99%

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An electronic technetium-99m-diethylenetriaminepentaacetic acid glomerular filtration rate spreadsheet with novel embedded quality assurance features

Klein

Razavi

Memon

et al. 2019

Nuclear Medicine Communications

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

An electronic technetium-99m-diethylenetriaminepentaacetic acid glomerular filtration rate spreadsheet with novel embedded quality assurance features

Klein

Razavi

Memon

et al. 2019

Nuclear Medicine Communications

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“…Table 1 gives an overview of the studies and the way we obtained mean GFR, SD and numbers for men and women from the 12 selected publications [6,[9][10][11][12][13][14][15][16][24][25][26] . Table 2 gives a detailed overview of the data for mean GFR, SD and numbers of men and women per age group, as we extracted them from these publications.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, the comparison between age groups 50-60 and 60-70 years (for all studies, except for Vervoort et al [24] , Hamilton et al [10] , Berg [14] and Holness et al [16] who did not have kidney donors in the last age group) gives an overall effect size of 0.55 with 95% CI of 0.42-0.67 (p < 0.0001) corresponding to a difference of 8.2 ml/ min/1.73 m 2 indicating that the decrease goes on at the same rate.…”

Section: Meta-analysis In Kidney Donorsmentioning

confidence: 99%

Glomerular Filtration Rate in Healthy Living Potential Kidney Donors: A Meta-Analysis Supporting the Construction of the Full Age Spectrum Equation

Pottel

Hoste

Yayo

et al. 2016

Nephron

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Background: Normal kidney function or, more specifically, normal glomerular filtration rate (GFR) in men and women and its decline with age is still much debated today. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation has gender (and race) multiplication factors, accounts for a decline that starts at very young age and assumes that the mean GFR is as high as 120-130 ml/min/1.73 m² from a young age. The full age spectrum (FAS) estimated mean GFR is about 107 ml/min/1.73 m² at a young age and remains constant until the age of 40 years and then starts to decline both in men and women. The aim of this research study was to give more insight into ‘normal' GFR levels and the physiological decrease of kidney function with age and to use a meta-analysis to evaluate the mathematical construction of the FAS and the CKD-EPI equation. Methods: We conducted a meta-analysis of published GFR measurements in healthy Caucasian living potential kidney donors (n = 5,482, 46.8% men). Only publications dating from 2000 were selected to avoid the possible influence of body surface area changes in the last decades on the indexed GFR, expressed in ml/min/1.73 m². Results: We found that the mean GFR ≈ 107 ml/min/1.73 m² up to the age of 40 years, but renal decline begins beyond 40 years. No evidence could be found for any difference between men and women in the separate age groups. Conclusions: The current meta-analysis supports the mathematical form of the FAS equation, which matches the age/sex dependency of measured GFR for healthy potential living kidney donors.

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“…The criteria that need to be fulfilled for this to be true are (1) that the radiolabeled compound (99mTc‐DTPA) need to distribute in the predicted manner (i.e., extracellularly) and (2) the activity recorded must reflect the amount of isotope and not be influenced by self‐absorption or the shape of the sample. It has been shown, both for 99mTc‐DTPA and Gd‐DTPA, that the distribution is extracellular, and this fact is used in, for example, viability imaging in CMR . As for self‐absorption, the half‐value layer of tissue for 99mTc seems to be around 4 cm which, if approximating the tissue to a cube with a density of 1 g/cm3, would correspond to a biopsy weighing 64 g .…”

Section: Discussionmentioning

confidence: 99%

Measuring extracellular volume fraction by MRI: First verification of values given by clinical sequences

Nordlund

Xanthis

Bidhult

et al. 2019

Magnetic Resonance in Med

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Funding information Swedish Heart and Lung foundation; Region of scania; Lund University Medical Faculty FoundationPurpose: To verify MR measurements of myocardial extracellular volume fraction (ECV) based on clinically applicable T1-mapping sequences against ECV measurements by radioisotope tracer in pigs and to relate the results to those obtained in volunteers. Methods: Between May 2016 and March 2017, 8 volunteers (25 ± 4 years, 3 female) and 8 pigs (4 female) underwent ECV assessment with SASHA, MOLLI5(3b)3, MOLLI5(3s)3, and MOLLI5s(3s)3s. Myocardial ECV was measured independently in pigs using a radioisotope tracer method. Results: In pigs, ECV in normal myocardium was not different between radioisotope (average ± standard deviation; 19 ± 2%) and SASHA (21 ± 2%; P = 0.086).ECV was higher by MOLLI5(3b)3 (26 ± 2%), MOLLI5(3s)3 (25 ± 2%), and MOLLI5s(3s)3s (25 ± 2%) compared with SASHA or radioisotope (P ≤ 0.001 for all). ECV in volunteers was higher by MOLLI5(3b)3 (26 ± 3%) and MOLLI5(3s)3 (26 ± 3%) than by SASHA (22 ± 3%; P = 0.022 and P = 0.033). No difference was found between MOLLI5s(3s)3s (25 ± 3%) and SASHA (P = 0.225). Native T1 of blood and myocardium as well as postcontrast T1 of myocardium was consistently lower using MOLLI compared with SASHA. ECV increased over time as measured by MOLLI5(3b)3 and MOLLI5(3s)3 for pigs (0.08% and 0.07%/min; P = 0.004 and P = 0.013) and by MOLLI5s(3s)3s for volunteers (0.07%/min; P = 0.032) but did not increase as measured by SASHA. Conclusion: Clinically available MOLLI and SASHA techniques can be used to accurately estimate ECV in normal myocardium where MOLLI-sequences show minor overestimation driven by underestimation of postcontrast T1 when compared with SASHA. The timing of imaging after contrast administration affected the measurement of ECV using some variants of the MOLLI sequence.

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99mTc-DTPA volume of distribution, half-life and glomerular filtration rate in normal adults

Abstract: Well-defined reference data for VD and T1/2 can be used for quality control checks in GFR investigations. In addition to these, reference data for GFR using Tc-DTPA have been defined. This will enhance the interpretation of adult Tc-DTPA GFR measurements.

Cited by 12 publications

References 31 publications

An electronic technetium-99m-diethylenetriaminepentaacetic acid glomerular filtration rate spreadsheet with novel embedded quality assurance features

An electronic technetium-99m-diethylenetriaminepentaacetic acid glomerular filtration rate spreadsheet with novel embedded quality assurance features

Glomerular Filtration Rate in Healthy Living Potential Kidney Donors: A Meta-Analysis Supporting the Construction of the Full Age Spectrum Equation

Measuring extracellular volume fraction by MRI: First verification of values given by clinical sequences

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