99mTc-EDDA/HYNIC-octreotate scintigraphy, an efficient method for the detection and staging of carcinoid tumours: results of 3 years’ experience

Hubalewska‐Dydejczyk, Alicja; Fröss-Baron, Katarzyna; Mikołajczak, Renata; Maecke, Helmut R.; Huszno, Bohdan; Pach, Dorota; Sowa‐Staszczak, Anna; Janota, Barbara; Szybiński, P.; Kulig, Jan

doi:10.1007/s00259-006-0113-7

Cited by 94 publications

(59 citation statements)

References 27 publications

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“…Tc-EDDA/HYNIC-TOC SPECT and whole body scintigraphy for detecting primary lung NETs or lung metastases is in agreement with previous reports [14,15]. Several factors may be responsible for our FN findings, such as an insufficient expression of SSTR2 for in-vivo detection by 99m Tc-EDDA/HYNIC-TOC or a comparably higher expression of other SSTR subtypes (SSTR3, SSTR4 or SSTR5) in our cases with low-differentiated tumors.…”

Section: Discussionsupporting

confidence: 82%

“…Semiquantitative results in our study confirm previously reported higher T/NT ratios on SPECT than whole body images [9,15]. As expected, therefore, SPECT should be preferred over whole body scintigraphy as it can more precisely detect and localize focal lung lesions.…”

Section: Discussionsupporting

confidence: 80%

“…As expected, therefore, SPECT should be preferred over whole body scintigraphy as it can more precisely detect and localize focal lung lesions. The previous study using In-Octreoscan for staging of carcinoids [15]. The reason for a higher uptake of 99m Tc-EDDA/HYNIC-TATE is its comparably higher potential to bind and internalize in tumor cells expressing SSTR2 than Tc-EDDA/HYNIC-TOC [18].…”

Section: Discussionmentioning

confidence: 99%

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The utility of 99mTc-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors

Pavlović¹,

Artiko²,

Šobić-Šaranović³

et al. 2010

neo

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Our aim was to assess clinical utility of 99m Tc-EDDA/HYNIC-TOC scintigraphy for evaluation of lung lesions in patients with neuroendocrine tumors (NETs). Single photon emission computed tomography (SPECT) of the thorax and whole body scintigraphy were performed in 34 patients using Tc-EDDA/HYNIC-TOC. Visual assessment was complemented by semiquantitative evaluation based on tumor to non-tumor (T/NT) ratio. Clinical, laboratory, and histological findings served as the standard for comparison. Enhanced tracer uptake was observed on both SPECT and whole body scintigraphy in 29 of 34 patients (88% sensitivity). T/NT ratios were significantly higher on SPECT than whole body images (2.96±1.07 vs.1.70±0.43, p<0.01) and did not correlate with NET proliferation index p=0.27). Conclusion: 99m Tc-EDDA/ HYNIC-TOC scintigraphy is useful for evaluation of NET tissue in the lungs. SPECT provides better visualization of lung lesions than whole body scintigraphy. The intensity of tracer uptake, however, does not relate to the proliferation rate of NETs. Tc-EDDA/HYNIC-TOC scintigraphy may be helpful for selecting and monitoring treatment options, particularly when radiolabeled somatostatin analogue therapy becomes available.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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The utility of 99mTc-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors

Pavlović¹,

Artiko²,

Šobić-Šaranović³

et al. 2010

neo

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“…26 There is also evidence to suggest that octreotide scans are useful in occult ACTH-secreting tumors, including those of bronchial origin. [26][27][28] …”

Section: Presentationmentioning

confidence: 99%

Pulmonary neuroendocrine/carcinoid tumors

Bertino

Confer

Colonna

et al. 2009

Cancer

133

123

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Neuroendocrine tumors are a unique malignant neoplasm that can arise from the respiratory tree. Although well-differentiated bronchial neuroendocrine tumors (also called carcinoid tumors) are reported to account for approximately 25% of all neuroendocrine tumors, they represent only 1% to 2% of all lung cancers. The epidemiology, clinical behavior, and treatment of neuroendocrine carcinoid tumors differ significantly from other lung malignancies. In this article, the recent data regarding these tumors were reviewed with attention to the treatment modalities used. Although conventional cytotoxic therapy has not been reported to demonstrate much promise in this entity over the past 4 decades, newer molecular targeted agents including those that targeted angiogenesis and the mammalian target of rapamycin (mTOR) Well-differentiated neuroendocrine, or carcinoid, tumors are a unique class of malignancies capable of producing hormones identical to those from the nervous system. Although the first carcinoid tumor described was in the ileum, neuroendocrine malignancies are a family of malignancies found throughout the body. Tumors of the bronchial tree in particular account for approximately 25% of all well-differentiated neuroendocrine tumors (Table 1). [1][2][3] However, compared with other malignancies of the bronchoalveolar tree, these well-differentiated neuroendocrine tumors are rare, accounting for only 1% of all lung cancers. 3 The pathologic spectrum of neuroendocrine malignancies ranges from low-grade carcinoid to aggressive small cell lung cancer. The low-grade and intermediate-grade neuroendocrine malignancies, also known as typical and atypical carcinoid, will be the focus of this review. The distinct features of this malignancy include its pathologic characteristics, clinical behavior, epidemiology, prognosis, and treatment.

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“…These tests can identify lesions undetected by anatomical imaging methods, increasing the chances of locating the primary focus and determining the actual stage of the neoplasm [6,[107][108][109]. They may also be the firstline method in the diagnostics of early recurrence, in monitoring the disease, and in choosing a suitable treatment.…”

Section: Radioisotope Diagnostics Of Pnensmentioning

confidence: 99%

Nowotwory neuroendokrynne trzustki — zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)

Kos–Kudła¹,

Rosiek²,

Borowska³

et al. 2017

Endokrynologia Polska

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99mTc-EDDA/HYNIC-octreotate scintigraphy, an efficient method for the detection and staging of carcinoid tumours: results of 3 years’ experience

Abstract: 99mTc-EDDA/HYNIC-octreotate, with high imaging quality, is an excellent alternative to 111In-Octreoscan for staging of carcinoids, and it seems to be the method of choice for detection of the primary focus in patients with metastases from an unknown primary tumour.

Cited by 94 publications

References 27 publications

The utility of 99mTc-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors

The utility of 99mTc-EDDA/HYNIC-TOC scintigraphy for assessment of lung lesions in patients with neuroendocrine tumors

Pulmonary neuroendocrine/carcinoid tumors

Nowotwory neuroendokrynne trzustki — zasady diagnostyki i leczenia (rekomendowane przez Polską Sieć Guzów Neuroendokrynych)

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