99mTc-GSA liver dynamic SPECT for the preoperative assessment of hepatectomy

Satoh, Katashi; Yamamoto, Yuka; Nishiyama, Yoshihiro; Wakabayashi, Hisao; Ohkawa, Motoomi

doi:10.1007/bf02988261

Cited by 52 publications

(60 citation statements)

References 11 publications

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“…Static 99m Tc-GSA SPECT has been introduced to improve the assessment of segmental liver function and to measure functional liver volume (33,(42)(43)(44). The outline extraction method is a simple technique to calculate functional liver volume using a specific cutoff value to automatically outline the liver (33).…”

Section: Kinetics and Quantitative Measurement Of Liver Functionmentioning

confidence: 99%

“…However, it does not incorporate regional functional differences within the included volume. Therefore, Satoh et al described a more precise method for calculating functional liver volume depending on the degree of 99m Tc-GSA radioactivity in each voxel (43). First, the voxel with maximal counts was determined.…”

Section: Kinetics and Quantitative Measurement Of Liver Functionmentioning

confidence: 99%

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Nuclear Imaging Techniques for the Assessment of Hepatic Function in Liver Surgery and Transplantation

Graaf¹,

Bennink²,

Veteläinen³

et al. 2010

J Nucl Med

140

120

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This review describes the application of 2 nuclear imaging techniques for assessment of hepatic function in the setting of liver surgery and transplantation. The biochemical and technical background, as well as the clinical applications, of 99m Tc-labeled diethylenetriaminepentaacetic acid galactosyl human serum albumin (GSA) scintigraphy and hepatobiliary scintigraphy (HBS) with 99m Tc-labeled iminodiacetic acid derivates is discussed. 99m Tc-mebrofenin is considered the most suitable iminodiacetic acid agent for 99m Tc-HBS. 99m Tc-GSA scintigraphy and 99m Tcmebrofenin HBS are based on 2 different principles. 99m Tc-GSA scintigraphy is a receptor-mediated technique whereas HBS represents hepatic uptake and excretion function. Both techniques are noninvasive and provide visual and quantitative information on both total and regional liver function. They can be used for preoperative assessment of future remnant liver function, follow-up after preoperative portal vein embolization, and evaluation of postoperative liver regeneration. In liver transplantation, these methods are used to assess graft function and biliary complications.

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Section: Kinetics and Quantitative Measurement Of Liver Functionmentioning

confidence: 99%

Section: Kinetics and Quantitative Measurement Of Liver Functionmentioning

confidence: 99%

Nuclear Imaging Techniques for the Assessment of Hepatic Function in Liver Surgery and Transplantation

Graaf¹,

Bennink²,

Veteläinen³

et al. 2010

J Nucl Med

140

120

View full text Add to dashboard Cite

show abstract

“…A reliable test assessing hepatic functional reserve, technetium-99m galactosyl human serum albumin ( 99m Tc-GSA) scintigraphy, has been used in patients with liver disease and this type of scintigraphy reflects asialoglycoprotein receptors of living liver cells [15]. 99m Tc-GSA scintigraphy can provide useful information concerning functional liver volume in any part of the liver [16], and this is clinically useful to determine the appropriate hepatectomy. This examination reflects the effect of PVE better than CT volumetry [17].…”

Section: Introductionmentioning

confidence: 99%

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Nanashima¹,

Tobinaga²,

Abo³

et al. 2010

Journal of Surgical Research

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“…[ 99m Tc]sestamibi likely enters hepatocytes passively and undergoes partial fecal clearance, as efflux is modulated by hepatocyte P-gp and the tracer undergoes preferential basolateral efflux into the bile. [ 99m Tc]galactosyl-human serum albumin is also used in Japan [17,47] to assess liver function, but is not a known transporter substrate.…”

Section: Mrimentioning

confidence: 99%

Noninvasive Preclinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury

Kenna

Waterton

Baudy

et al. 2018

Methods in Pharmacology and Toxicology

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Imaging technologies can evaluate many different biological processes in vitro (in cell culture models) and in vivo (in animals and humans), and many are used routinely in investigation of human liver diseases. Some of these methods can help understand liver toxicity caused by drugs in vivo in animals, and druginduced liver injury (DILI) which arises in susceptible humans. Imaging could aid assessment of the relevance to humans in vivo of toxicity caused by drugs in animals (animal/human translation), plus toxicities observed using in vitro model systems (in vitro/in vivo translation). Technologies and probe substrates for quantitative evaluation of hepatobiliary transporter activities are of particular importance. This is due to the key role played by sinusoidal transporter mediated hepatic uptake in DILI caused by many drugs, plus the strong evidence that inhibition of the hepatic bile salt export pump (BSEP) can initiate DILI. Imaging methods for investigation of these processes are reviewed in this chapter, together with their scientific rationale, and methods of quantitative data analysis. In addition to providing biomarkers for investigation of DILI, such approaches could aid the evaluation of clinically relevant drug-drug interactions mediated via hepatobiliary transporter perturbation.

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99mTc-GSA liver dynamic SPECT for the preoperative assessment of hepatectomy

Abstract: When PRI is above 0.38, there is a low probability of hepatic failure after hepatectomy. The PRI is useful in preoperative prediction of post-hepatectomy residual liver function in patients with liver disease.

Cited by 52 publications

References 11 publications

Nuclear Imaging Techniques for the Assessment of Hepatic Function in Liver Surgery and Transplantation

Nuclear Imaging Techniques for the Assessment of Hepatic Function in Liver Surgery and Transplantation

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Noninvasive Preclinical and Clinical Imaging of Liver Transporter Function Relevant to Drug-Induced Liver Injury

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