99mTc-Hexamethylpropylene Amineoxime Leukocyte Scintigraphy in Acute Pancreatitis: An Alternative to Contrast-Enhanced Computed Tomography?

Abstract

Our results show that leukocytes are related to the severity of local pancreatic damage in AP. Thus, LLS is a potential alternative technique to CECT for staging AP.

PET/CT with 18F-FDG–Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis

“…Previous studies in which scintigraphy with radionuclidelabeled leukocytes was used to detect infected pancreatic necrosis were limited to g-camera scintigraphy with leukocytes labeled with 111 In (5,6) or 99m Tc (7)(8)(9)(10). The use of 67 Ga SPECT/CT imaging, with high sensitivity and specificity, was also reported in this clinical context (23).…”

“…Some authors have shown the usefulness of radionuclide-labeled leukocyte scintigraphy for the detection of infected pancreatic necrosis in patients with AP (5-10) and have even suggested it as an alternative to CECT for staging AP (10). However, these studies were limited to g-camera scintigraphy with leukocytes labeled with 111 In (5) or 99m Tc (7)(8)(9)(10), and image quality and resolution were unsatisfactory.…”

“…However, these studies were limited to g-camera scintigraphy with leukocytes labeled with 111 In (5) or 99m Tc (7)(8)(9)(10), and image quality and resolution were unsatisfactory.…”

Pancreas and Cystic Fibrosis: The Implications of Increased Survival in Cystic Fibrosis

“…In a previous study we concluded that LLS could be an alternative technique to CECT for staging AP [23] . We have now extended that work by using a larger prospective series of patients with AP to evaluate specifically the utility of LLS with 99m Tc-HMPAO in the diagnosis of PN.…”

“…Several authors have shown the usefulness of scintigraphy using radionuclide-labeled leukocytes, a safe and non-invasive technique, as an indicator of pancreatic damage in patients with AP [17][18][19][20][21][22] . In previous research, we concluded that labeled leukocyte scintigraphy (LLS) may be an alternative to CECT for staging AP [23] .…”