99mTc-labeled keratin gold-nanoparticles in a nephron-like microfluidic chip for photo-thermal therapy applications

Frantellizzi, Viviana; Verrina, V.; Raso, C.; Pontico, Mariano; Petronella, Francesca; Bertana, V.; Ballesio, Alberto; Miglietta, Selenia; Rosa, Paolo; Scibetta, Sofia; Petrozza, Vincenzo; Feo, Maria Silvia De; Vincentis, Giuseppe De; Calogero, Antonella; Pani, R.; Perotto, Giovanni; Sio, Luciano De

doi:10.1016/j.mtadv.2022.100286

Cited by 23 publications

(16 citation statements)

References 91 publications

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“…Combination of both PTT and immunotherapy could be considered especially regarding the results of few teams who show in mice the power of this combination, not only on the primary tumor but also on distant metastatic tumors. − This abscopal effect, usually observed with the combination of radiotherapy and immunotherapy, is still not completely understood but could be a solution to the bad prognosis of advanced metastatic melanoma. Besides the therapeutic effect, GNPs could also be a wonderful diagnostic tool as it is described in the literature. − Even if this study only focused on the therapeutic effect of photothermal therapy using our 15 nm round-shape gGNPs, this nanotheranostic shows strong potential for therapy in different kinds of cancer, using different properties of gGNPs (PTT, photodynamic therapy, drug carrier) as well as in diagnostics.…”

Section: Discussionmentioning

confidence: 99%

Impact of Green Gold Nanoparticle Coating on Internalization, Trafficking, and Efficiency for Photothermal Therapy of Skin Cancer

Bonamy

Pesnel²,

Haddada³

et al. 2023

ACS Omega

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Skin cancer is a global health issue and mainly composed of melanoma and nonmelanoma cancers. For the first clinical proof of concept on humans, we decided to study good prognosis skin cancers, i.e., carcinoma basal cell. In UE, the first-line treatment remains surgical resection, healing most of the tumors, but presents aesthetic disadvantages with a high reoccurrence rate on exposed areas. Moreover, the therapeutic indications could extend to melanoma and metastasis, which is a different medical strategy that could combine this treatment. Indeed, patients with late-stage melanoma are in a therapeutic impasse, despite recent targeted and immunological therapies. Photothermal therapy using gold nanoparticles is the subject of many investigations due to their strong potential to treat cancers by physical, thermal destruction. We developed gold nanoparticles synthesized by green chemistry (gGNPs), using endemic plant extract from Reunion Island, which have previously showed their efficiency at a preclinical stage. Here, we demonstrate that these gGNPs are less cytotoxic than gold nanoparticles synthesized by Turkevich’s method. Furthermore, our work describes the optimization of gGNP coating and stabilization, also taking into consideration the gGNP path in cells (endocytosis, intracellular trafficking, and exocytosis), their specificity toward cancerous cells, their cytotoxicity, and their in vivo efficiency. Finally, based on the metabolic switch of cancerous cells overexpressing Glut transporters in skin cancers, we demonstrated that glucose-stabilized gGNP (gGNP@G) enables a quick internalization, fourfold higher in cancerous cells in contrast to healthy cells with no side cytotoxicity, which is particularly relevant to target and treat cancer.

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Section: Discussionmentioning

confidence: 99%

Impact of Green Gold Nanoparticle Coating on Internalization, Trafficking, and Efficiency for Photothermal Therapy of Skin Cancer

Bonamy

Pesnel²,

Haddada³

et al. 2023

ACS Omega

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“…The investigation pointed out the dynamic stability of 99m Tc-DTPA-Ker-AuNPs, the preservation of the photothermal properties of gold nanoparticles, and the suitability of the 99m Tc-DTPA-Ker -GNP as a radiotracer for the SPECT imaging technique. Our study pays the way for the development of new theragnostic strategies potentially able to perform multimodal tumor treatments [ 123 ]. Indeed, further studies and integrated strategies for cancer treatment by merging PTT ablation with chemotherapy-selective drug delivery or PTT for radiotherapy sensitization purposes are needed.…”

Section: Discussionmentioning

confidence: 99%

18F-fluorodeoxyglucose (18F-FDG) Functionalized Gold Nanoparticles (GNPs) for Plasmonic Photothermal Ablation of Cancer: A Review

et al. 2023

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The meeting and merging between innovative nanotechnological systems, such as nanoparticles, and the persistent need to outperform diagnostic-therapeutic approaches to fighting cancer are revolutionizing the medical research scenario, leading us into the world of nanomedicine. Photothermal therapy (PTT) is a non-invasive thermo-ablative treatment in which cellular hyperthermia is generated through the interaction of near-infrared light with light-to-heat converter entities, such as gold nanoparticles (GNPs). GNPs have great potential to improve recovery time, cure complexity, and time spent on the treatment of specific types of cancer. The development of gold nanostructures for photothermal efficacy and target selectivity ensures effective and deep tissue-penetrating PTT with fewer worries about adverse effects from nonspecific distributions. Regardless of the thriving research recorded in the last decade regarding the multiple biomedical applications of nanoparticles and, in particular, their conjugation with drugs, few works have been completed regarding the possibility of combining GNPs with the cancer-targeted pharmaceutical fluorodeoxyglucose (FDG). This review aims to provide an actual scenario on the application of functionalized GNP-mediated PTT for cancer ablation purposes, regarding the opportunity given by the 18F- fluorodeoxyglucose (18F-FDG) functionalization.

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“…In this context, the study of Xing et al in which generation five PAMAM dendrimers (G5.NH2) were conjugated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), polyethylene glycol (PEG) modified duramycin, PEG monomethyl ether, and fluorescein isothiocyanate (FI). Then gold nanoparticles were entrapped, and the compound was radiolabeled with 99m Tc [ 35 , 36 ]. They exploited the affinity of duramycin for phosphatidylethanolamine (PE), a protein that is expressed by cells during apoptosis, to develop a SPECT imaging tool for apoptotic cells.…”

Section: Discussionmentioning

confidence: 99%

Radiolabeled Dendrimer Coated Nanoparticles for Radionuclide Imaging and Therapy: A Systematic Review

et al. 2023

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Background: Dendrimers are nanoscale-size polymers with a globular structure. They are composed of an internal core and branching dendrons with surface active groups which can be functionalized for medical applications. Different complexes have been developed for imaging and therapeutic purposes. This systematic review aims to summarize the development of newer dendrimers for oncological applications in nuclear medicine. Methods: An online literature search was conducted on Pubmed, Scopus, Medline, Cochrane Library, and Web Of Science databases selecting published studies from January 1999 to December 2022. The accepted studies considered the synthesis of dendrimer complexes for oncological nuclear medicine imaging and therapy. Results: 111 articles were identified; 69 articles were excluded because they did not satisfy the selection criteria. Thus, nine duplicate records were removed. The remaining 33 articles were included and selected for quality assessment. Conclusion: Nanomedicine has led researchers to create novel nanocarriers with high affinity for the target. Dendrimers represent feasible imaging probes and therapeutic agents since, through the functionalization of external chemical groups and thanks to the possibility to carry pharmaceuticals, it can be possible to exploit different therapeutic strategies and develop a useful weapon for oncological treatments.

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99mTc-labeled keratin gold-nanoparticles in a nephron-like microfluidic chip for photo-thermal therapy applications

Cited by 23 publications

References 91 publications

Impact of Green Gold Nanoparticle Coating on Internalization, Trafficking, and Efficiency for Photothermal Therapy of Skin Cancer

Impact of Green Gold Nanoparticle Coating on Internalization, Trafficking, and Efficiency for Photothermal Therapy of Skin Cancer

18F-fluorodeoxyglucose (18F-FDG) Functionalized Gold Nanoparticles (GNPs) for Plasmonic Photothermal Ablation of Cancer: A Review

Radiolabeled Dendrimer Coated Nanoparticles for Radionuclide Imaging and Therapy: A Systematic Review

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