99mTc-MAA Pulmonary Scintigraphy in Hereditary Hemorrhagic Telangiectasia

Yang, Fang; Yuan, Leilei; Ma, Ding; Yang, Jigang

doi:10.1097/rlu.0000000000001249

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…As reported in recent studies, ICG has a property of binding with plasma proteins fast, and it is to some extent distributed in normal lungs . Moreover, the clinic drug 99m Tc-MAA is a kind of albumin complex, proven to be effective for pulmonary perfusion imaging. , The NIRF unit of Gd-NMC-3, DCDSTCY, is a derivative of ICG. According to the above-mentioned evidence, Gd-NMC-3, similar to 99m Tc-MAA and ICG, is strongly likely to bind with plasma proteins to form complexes and accumulate in the lungs.…”

Section: Resultsmentioning

confidence: 96%

Tumor-Targeting NIRF/MR Dual-Modal Molecular Imaging Probe for Surgery Navigation

Xue

Wang

et al. 2022

Anal. Chem.

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Multimodality imaging recognized as a promising monitoring strategy can serve the needs of accurate diagnosis and treatment of cancer by providing molecular and anatomic information about tumor sites. However, the probes based on multiple imaging modalities for surgery navigation remain limited due to poor biocompatibility and tumor targeting specificity. Herein, we present a small-molecule near-infrared fluorescence/magnetic resonance (NIRF/MR) imaging probe, Gd-NMC-3, covalently coupled with DCDSTCY and Gd-DOTA via butane diamine, for precise detection and intraoperative visualization. The in vitro and in vivo studies demonstrated that Gd-NMC-3 could be effectively accumulated in tumor sites as a bimodal imaging molecule exhibiting significant fluorescence accumulation and reasonable relaxation property in tumors with low cytotoxicity and good biocompatibility. Furthermore, Gd-NMC-3 was successfully applied to provide real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors. Importantly, no more fluorescence was observed in mice after operation, implying the total removal of tumor tissues. In conclusion, Gd-NMC-3 has great potential to be applied in the clinic based on its high resolution and sensitivity in tumor imaging.

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Section: Resultsmentioning

confidence: 96%

Tumor-Targeting NIRF/MR Dual-Modal Molecular Imaging Probe for Surgery Navigation

Xue

Wang

et al. 2022

Anal. Chem.

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Hepatopulmonary Syndrome Mimics Pulmonary Embolism on Pulmonary Ventilation/Perfusion SPECT/CT Study

Zhang

Wang

et al. 2020

Clin Nucl Med

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A 64-year-old woman with a history of cirrhosis and progressive difficulty breathing underwent pulmonary ventilation/perfusion SPECT to evaluate possible pulmonary embolism. The images demonstrated multiple mismatched ventilation/perfusion defects in both lungs, suggesting pulmonary embolism. However, there was also 99mTc-MAA radioactivity in the brain and bilateral kidney, with a right-to-left shunting rate of 8.8%. In addition, CT pulmonary angiography did not demonstrate embolus. The findings indicated that perfusion defects were caused by hepatopulmonary syndrome.

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99mTc-MAA Pulmonary Scintigraphy in Hereditary Hemorrhagic Telangiectasia

Cited by 2 publications

References 26 publications

Tumor-Targeting NIRF/MR Dual-Modal Molecular Imaging Probe for Surgery Navigation

Tumor-Targeting NIRF/MR Dual-Modal Molecular Imaging Probe for Surgery Navigation

Hepatopulmonary Syndrome Mimics Pulmonary Embolism on Pulmonary Ventilation/Perfusion SPECT/CT Study

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