99mTc-MDP Bone Scan In the Detection of Bone Metastases in Breast cancer.

Peepre, Karan

doi:10.9790/0853-13148286

IOSRJDMS

2014

DOI: 10.9790/0853-13148286

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99mTc-MDP Bone Scan In the Detection of Bone Metastases in Breast cancer.

Karan Peepre¹

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Cited by 3 publications

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“…Generally, lymphatic system plays an important role in distribution of malignant cells, but the tumor marker is helpful in determining the extent of the spread of breast cancer, especially spinal metastases (9,10). The bone scintigraphy by 99m Tc-bisphosphonates is a well-known method to diagnose bone metastasis (11). To avoid false positive results, a comprehensive patient's history should be taken (12,13).…”

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confidence: 99%

Correlation of cancer antigen 15-3 (CA15-3) serum level and bony metastases in breast cancer patients

Fakhari

Gharepapagh

Oskuei

et al. 2019

Med. J. Islam. Republ. Iran

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Background: Cancer antigen 15-3 (CA15-3) is a common tumor marker and the serum level of this tumor marker is evaluated during the treatment period (periodically) in breast cancer patients. Assuming that the elevated serum levels of this tumor marker can be a potential risk, this study was conducted to determine the association between CA15-3 and bone metastasis and CA15-3 and metastasis spreading rate in breast cancer patients. Methods: In this study, 70 women with the mean of age 51.69 (10.77) years who suffered from breast cancer were studied by performing both bone scintigraphy and measuring CA15-3. Independent sample t test, Fisher's exact test, Spearman rho correlation, and logistic regression were used for inferential section. To determine the new cross section, Roc curve and coordinates of the curve were applied. Also, significance level was set at p<0.05. Data were analyzed by SPSS 16 software. Results: There was no difference among patients in age (p=0.123). Assuming the CA15-3 (≥ 30 U/mL) as a potential risk, there was no association between CA15-3 and bone metastases (p=0.167). Based on Spearman's rank correlation coefficient, there was no significant correlation between CA15-3 and metastasis spreading rate (r=-0.07, p=0.851). Based on ROC curve and Youden's J statistic index, the new cutoff was pointed at CA15-3 ≥21.76 Unit/mL, which correlated with bone metastases (p<0.001). Conclusion: This study found a decreased cutoff point at CA15-3 (≥21.76) against 30 (routine value). Based on CA15-3 (≥21.76), there was a correlation between bone metastases and CA15-3, indicating that patients with CA15-3 (≥21.76) were most likely to experience bone metastases.

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mentioning

confidence: 99%

Correlation of cancer antigen 15-3 (CA15-3) serum level and bony metastases in breast cancer patients

Fakhari

Gharepapagh

Oskuei

et al. 2019

Med. J. Islam. Republ. Iran

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Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component

Iqbal¹,

Naeem²,

Imran³

et al. 2019

Pak J Nucl Med

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Comparison of irregular flux viewer system with BONENAVI version for identification of Tc-99m MDP whole body bone scan metastasis images

Ting²,

Yang

et al. 2021

XST

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The Tc-99m methylene diphosphonate (MDP) whole body bone scan (WBBS) has been widely accepted as a method of choice for the initial diagnosis of bone and joint changes in patients with oncologic diseases. The WBBS has shown high sensitivity but relatively low specificity due to bone variation. This study aims to use the self-developing irregular flux viewer (IFV) system to predict possible bone lesions in planar WBBS. The study uses gradient vector flow (GVF) and self-organizing map (SOM) methods to analyze the blood fluid-dynamics and evaluate hot points. The evaluation includes a selection of 368 patients with bone metastasis from prostate cancer, lung cancer and breast cancer. Finally, we compare IFV values with BONENAVI version data. BONENAVI is a computer-assisted diagnosis system that analyzes bone scintigraphy automatically. The analysis shows that the IFV system achieves sensitivities of 93% for prostate cancer, 91% for breast cancer, and 83% for lung cancer, respectively. On the other hand, our proposed approach achieves a higher sensitivity than the results of BONEVAVI version 2.0.5 for prostate cancer (88%), breast cancer (86%) and lung cancer (82%), respectively. The study results demonstrate that the high sensitivity and specificity of the IFV system can provide assistance for image interpretation and generate prediction values for WBBS.

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99mTc-MDP Bone Scan In the Detection of Bone Metastases in Breast cancer.

Cited by 3 publications

References 8 publications

Correlation of cancer antigen 15-3 (CA15-3) serum level and bony metastases in breast cancer patients

Correlation of cancer antigen 15-3 (CA15-3) serum level and bony metastases in breast cancer patients

Skeletal metastatic distribution of HCC on 99mTc-MDP bone scan with a unique feature of soft tissue component

Comparison of irregular flux viewer system with BONENAVI version for identification of Tc-99m MDP whole body bone scan metastasis images

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