99mTc-scintimammography in the diagnosis of non-palpable breast lesions in relation to the mammographical probabilities of malignancy and microcalcifications

Carril, J.M.; Uriarte, Isabel; Quirce, R.; Montero, Alfonso; Vallina, N K; Vega, Alfonso; Hemandez, A.

doi:10.1016/s0959-8049(98)80286-4

Cited by 3 publications

(4 citation statements)

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“…Before the possibility of breast cancer is ruled out, a patient who receives a positive result is recalled for further examination that usually includes ultrasound imaging, needle biopsy, and sometimes surgical biopsies. These biopsies, which some authors call "unnecessary" [23,24], as well as the prolonged uncertainty about ones' health status, can be accompanied by a psychological trauma similar to those who were diagnosed with cancer in their first 6 months with symptoms such as short-term anxiety, more frequent self-examinations, and a change in the patients' tendency to attend later mammography sessions [25][26][27][28]. It has also been reported that 27 and 33% of women gone under breast biopsy had reduced sexual sensitivity and pain in the breast.…”

Section: False-positive Resultsmentioning

confidence: 99%

Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography

Ghanbarzadeh-Dagheyan¹,

Molaei²,

Obermeier³

et al. 2017

New Perspectives in Breast Imaging

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According to global statistics, there is a high incidence of cancer in western countries; and, due to the limited resources available in most health care systems, it seems like one of the most feasible options to fight against cancer might be strict prevention policiessuch as eliminating carcinogens in people's daily lives. Nevertheless, early cancer detection and effective treatment are still necessary, and understanding their efficacy and limitations are important issues that need to be addressed in order to ultimately enhance patients' survival rate. In the case of breast cancer, some of the problems faced by conventional mammography have been addressed in the literature; they include high rate of false-positive and false-negative results, as well as the possibility of overdiagnosis. New technologies, such as digital breast tomosynthesis (DBT), have been able to improve the sensitivity and specificity by using 3D imaging. However, the low contrast (1%) existing between tumors and healthy fibroglandular tissue at X-ray frequencies has been identified as one of the main causes of misdiagnosis in both conventional 2D mammography and DBT. Near-field radar imaging (NRI) provides a unique opportunity to overcome this problem, since the contrast existing between the aforementioned tissues is intrinsically higher (10%) at microwave frequencies. Moreover, the low resolution and highly complex scattering patterns of microwave systems can be enhanced by using prior information from other modalities, such as the DBT. Therefore, a multimodal DBT/NRI imaging system is proposed to exploit their individual strengths while minimizing their weaknesses. In this work, the foundation of this idea is reviewed, and a preliminary design and experimental validation of the NRI system, used as a DBT complement, is introduced.

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Section: False-positive Resultsmentioning

confidence: 99%

Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography

Ghanbarzadeh-Dagheyan¹,

Molaei²,

Obermeier³

et al. 2017

New Perspectives in Breast Imaging

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“…It has also been established by the same authors that the addition of SMM to MG may reduce the number of unnecessary biopsies in nonpalpable breast lesions by up to 55%. 17 Nevertheless, different results and suggestions have been reported recently by Flanagan et al, who enrolled 79 women with palpable breast mass and abnormal MG. They found a SMM sensitivity, specificity, and PPV of 81%, 81%, and 61% respectively, but their conclusion was that SMM does not increase the specificity of conventional MG and physical examination in diagnosing or excluding breast cancer.…”

Section: Discussionmentioning

confidence: 95%

Breast Cancer Detection With 99m-Tc-Sestamibi Scintigraphy, Mammography, and Fine-Needle Aspiration Cytology: Comparative Study in 64 Surgically Treated Patients

et al. 1999

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“…From our data, scintimammography was found to be a highly specific method for differentiating benign and malignant breast lesions, but sensitivity in detecting breast cancer was low (combined planar and SPECT: 57 %). Considering that most of the lesions were not palpable, we compared our results with previous studies [17,19,21,22,23,26,27,28], which reported a sensitivity ranging from 21 to 89 % in detecting non-palpable breast carcinomas. With respect to tumor size, concurrently low sensitivity of scintigraphy in detecting breast cancer smaller than 1 cm was reported [22,32].…”

Section: Discussionmentioning

confidence: 97%

“…Scintigraphy with Tc-99m sestamibi has also been proposed to visualize malignant breast tumors [17,18,19,20,21,22,23,24,25,26,27,28,29]. In a meta-analysis, Taillefer [30] reported an overall sensitivity of 85 % and a specificity of 89 % in detecting breast cancer, with a wide range, depending on inclusion and evaluation criteria; however, the value of this method in a multimodal context is not well established.…”

mentioning

confidence: 99%

Comparison of dynamic MR imaging of the breast and sestamibi scintimammography for evaluation of indeterminate mammographic lesions

et al. 2001

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The aim of this study was to compare Tc-99m sestamibi scintimammography and dynamic contrast-enhanced MR imaging for the evaluation of indeterminate mammographic lesions. Forty patients with questionable mammographic findings were included in a prospective study. Thirty lesions were non-palpable. Mean lesion size was 1.6+/-0.7 cm (range 0.5-3.5 cm). Scintigraphy was considered as malignant when focal tracer accumulation was present. In MR imaging, lesions were classified according to their signal intensity time course: no enhancement or steady enhancement with low signal intensity (M0); steady enhancement with high signal intensity (M1); or rapid enhancement with plateau (M2) or washout (M3). Lesions classified as M2 or M3 were considered as suspicious for malignancy. Histopathologic evaluation was performed in 24 lesions. In 16 cases lesions were classified as benign from follow-up examinations (mean 24 months). Malignancies were proven in 14 patients (9 invasive carcinomas, 5 ductal carcinoma in situ). Sensitivity of MR imaging was 12 of 14 (86%) and sensitivity of scintimammography was 8 of 14 (57%). One of 26 benign lesions was false positive at MR imaging. Scintigraphy showed no false-positive results. In conclusion, magnetic resonance imaging provided high accuracy in evaluation of indeterminate mammographic lesions. Sensitivity of scintimammography was too low in detecting small carcinomas.

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99mTc-scintimammography in the diagnosis of non-palpable breast lesions in relation to the mammographical probabilities of malignancy and microcalcifications

Cited by 3 publications

References 0 publications

Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography

Near-Field Radar Microwave Imaging as an Add-on Modality to Mammography

Breast Cancer Detection With 99m-Tc-Sestamibi Scintigraphy, Mammography, and Fine-Needle Aspiration Cytology: Comparative Study in 64 Surgically Treated Patients

Comparison of dynamic MR imaging of the breast and sestamibi scintimammography for evaluation of indeterminate mammographic lesions

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