99mTc tetrofosmin scintigraphy in acute leukaemia: the relationship between marrow uptake of tetrofosmin and P-glycoprotein and chemotherapy response

Sükan, Aysun; Yapar, Zeynep; Şahin, Berksoy; Kara, Oǧuz; Yapar, Alı Fuat; Çetíner, Salíh; Ki̇bar, Mustafa

doi:10.1097/01.mnm.0000134319.32279.0f

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…99m Tc is easily available and tumor imaging agents labeled by it have been developed quickly. TF is a lipophic, cationic diphosphate initially developed for myocardial imaging, and several researches have confirmed its accumulation in tumors [1][2][3][4] .…”

Section: Discussionmentioning

confidence: 99%

The clinical usefulness of 99mTc-Tetrofosmin scintigraphy in the diagnosis of lung neoplasmas and mediastinal lymphoid node involvement

Huang

Zhao

Zhang

2008

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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In order to investigate the clinical significance of (99m)Tc-Tetrofosmin (TF) scintigraphy in the evaluation of lung cancer and mediastinal lymphoid node involvement, 33 patients with pulmonary neoplasmas were subjected to both (99m)Tc-TF scintigraphies and CT scans in one week before their operations or puncturations. All the images were judged visually and the emission images were analyzed with semi-quantitative methods in addition. The results of each group were compared. There was marked difference in target/non-target (T/N) ratio between the lung cancer group and the benign lesion group (P<0.001). Moreover, in the lung cancer group, T/N ratio in tomographies was significantly higher than that in planar images (P<0.01). The sensitivity and accuracy of semi-quantitative analysis in (99m)Tc-TF SPECT were significantly higher than those of CT in the diagnosis of pulmonary neoplasmas (P<0.05 and P<0.01 respectively), so was the sensitivity of (99m)Tc-TF SPECT vs CT in the diagnosis of mediastinal lymphoid node metastasis (P<0.05). It was also found that epidermoid squamous cell carcinomas and adenocarcinomas had a higher T/N ratio than in small cell carcinomas (P<0.05), and 2 h washout rate (WR) of adenocarcinomas was higher than that of epidermoid squamous cell carcinomas (P<0.05). In conclusion, (99m)Tc-TF scintigraphy showed a favorable diagnostic accuracy in appraising lung cancers and mediastinal lymph node metastases. Furthermore semi-quantitative technology can improve the accuracy, and is potential to offer some information about histological type of the cancer tissue. Therefore, (99m)Tc-TF scintigraphy will be a useful tool in the diagnosis and staging of lung cancer.

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Section: Discussionmentioning

confidence: 99%

The clinical usefulness of 99mTc-Tetrofosmin scintigraphy in the diagnosis of lung neoplasmas and mediastinal lymphoid node involvement

Huang

Zhao

Zhang

2008

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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“…Tetrofosmin is a perfusion agent, 25 and is an indicator of cell viability. 26,27 Kresnik et al 8 reported decreased tetrofosmin uptake in patients with degenerative goiter and HT in a late scan obtained at 1 h after injection. In other study, Younes et al 25 showed that the mechanism of tetrofosmin uptake was dependent on the amount of mitochondrial proteins using cell-based systems.…”

Section: Fi Gu Rementioning

confidence: 99%

“…[31][32][33] The re are few re ports abo ut the use of Tc-99m tet ro fos min in di ag no sing apopto sis. Sü kan et al 26 sho wed that sig ni fi cantly in crea sed Tc-99m tet ro fos min up ta ke in to the bo ne mar row was well cor re la ted with CD95, an in hi bitor of apop to sis in pa ti ents with acu te le u ke mi a. Wa ka su gi et al 27 re por ted a ca se of ma lig nant pheoc hro mocy to ma that sho wed early in ten se up ta ke and im me di a te ra pid wash-out of Tc-99m tet ro fosmin. They al so cha rac te ri zed ove rex pres si on of the an ti-apop to tic mo le cu le Bcl-2 in this ca se, which was ref rac tory to I-131 MIBG the rapy.…”

Section: Fi Gu Rementioning

confidence: 99%

Changes of Thyroidal Tc-99m Tetrofosmin Uptake and Wash-Out in Patients with Hashimoto’s Thyroiditis

Yüksel¹,

Fenkci²,

Kıraç³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Our aim was to in ves ti ga te the chan ges in Tc-99m tet ro fos min up ta ke and wash-out in the thyro id gland of nor mal vo lun te ers and Has hi mo to's thyro i di tis (HT) pa tients with eit her euth yro i dism or hypoth yro i dism. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Thirty-fo ur pa ti ents with HT (10 hypoth yro id and 24 euth yro id) and 10 euth yro id he althy vo lun te ers we re en rol led in the study. In all ca ses, thyroid stimulating hormone (TSH), fre e thyro xi ne (FT4), fre e tri i odoth yro ni ne (FT3), an ti-thyro id an ti bo di es and thyro id vo lu me we re me a su red. An te ri or thyroid ima ges we re ac qu i red at 10, 30 and 120 min af ter in tra ve no us in jec ti on of 740 MBq Tc-99m tet ro fos min. Thyro id/ back gro und (T/B) ra ti os at 10, 30 and 120 min and wash-out in di ces (WI %) at 30 and 120 min we re cal cu la ted. R Re e s su ul lt ts s: : In all gro ups, ini ti al and la te tet ro fos min T/B va lu es did not dif fer from he althy con trol ca ses. At 120 min, the me an WI% of pa ti ents with hypothyro i dism was sig ni fi cantly hig her than that of vo lun te ers; ho we ver this gro up is not sta tis ti cally dif fe rent from the euth yro id gro up. The va lu e WI % at 120 min was sig ni fi cantly cor re la ted with an ti-Tg an ti body le vels (r= -0.673; p= 0.033). In the euth yro id gro up, both an ti-TPO an ti body le vels and thyro id vo lu me had sig ni fi cant cor re la ti ons with the T/B ra ti os at 10, 30 and 120 min (r= 0.499, p= 0.013; r= 0.424, p= 0.039; r=0.528, p= 0.008 for An ti-TPO An ti body, and r= 0.577, p= 0.003; r= 0.606, p= 0.002; r= 0.645, p= 0.010, for thyro id vo lu me, res pec ti vely). C Co on nc c l lu u s si i o on n: : We can conc lu de that Tc-99m tet ro fos min up ta ke and wash-out ki ne tics in thyro id tis su e may be chan ged with au to im mu ne thyrocy te des truc ti on in HT.K Ke ey y W Wo or rd ds s: : Tech ne ti um Tc 99m tetrofosmin; Has hi mo to di se a se; ra di o nuc li de ima ging Ö ÖZ ZE ET T A Am ma aç ç: : Ama cı mız öti ri o i dizm ve ya hi po ti ro i dizm li Has hi mo to Ti ro i dit li (HT) has ta la rın ve sağ lık lı gö nül lü le rin ti ro id be zin de ki Tc-99m tet ro fos min tu tu lum ve atı lı mın da ki de ği şik lik le ri araş tır mak tı. G Ge e r re eç ç v ve e Y Yö ön n t te em ml le er r: : Has hi mo to Ti ro i dit li 34 has ta (10'u hi po ti ro id ve 24'ü öti ro id) ve 10 öti ro id sağ lık lı gö nül lü ça lış ma ya alın dı. Tüm ol gu la rın tiroid stimule edici hormon (TSH), serbest ti rok sin (FT4), ser best tri i yo do ti ro nin (FT3), an ti-ti ro id an ti kor dü zey le ri ve ti ro id ha cim le ri öl çül dü. İntra ve nöz ola rak 740 MBq Tc-99m tet ro fos min en jek si yo nun dan son ra 10, 30 ve 120 daki ka lar da an te ri or ti ro id gö rün tü le ri alın dı. Bu gö rün tü ler den 10, 30, 120 dk ti ro id/ze min ak ti vi te (T/B) oran la rı ve 30 ve 120 da ki ka da ki "wash-ou t" in deks le ri (%WI) he sap lan dı. B Bu ul l g gu u ...

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“…Pathologic uptake of Tc-99m tetrofosmin can occur in benign or malignant tumors and also in infectious or non-infectious diseases (Vijayakumar et al, 2005). The mechanism of uptake of Tc-99m tetrofosmin in non-cardiac lesions is not completely understood, but the size of the lesion, its mitochondrial-rich cellularity and perfusion (factors) play a significant role (Kinuya et al, 2003;Sükan et al, 2004). Over-expression of P-glycoprotein or multi-drug resistance can decrease tumor uptake and are also associated with resistance to cancer treatment.…”

Section: Incidental Pathologic Extra-cardiac Findings During Mpimentioning

confidence: 99%

Clinical Significance of Tetrofosm in Extracardiac Uptake During Myocardial Perfusion Imaging

Georgoulias¹,

Valotassiou²,

Tsougos³

et al. 2011

Coronary Angiography - Advances in Noninvasive Imaging Approach for Evaluation of Coronary Artery Disease

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99mTc tetrofosmin scintigraphy in acute leukaemia: the relationship between marrow uptake of tetrofosmin and P-glycoprotein and chemotherapy response

Cited by 6 publications

References 38 publications

The clinical usefulness of 99mTc-Tetrofosmin scintigraphy in the diagnosis of lung neoplasmas and mediastinal lymphoid node involvement

The clinical usefulness of 99mTc-Tetrofosmin scintigraphy in the diagnosis of lung neoplasmas and mediastinal lymphoid node involvement

Changes of Thyroidal Tc-99m Tetrofosmin Uptake and Wash-Out in Patients with Hashimoto’s Thyroiditis

Clinical Significance of Tetrofosm in Extracardiac Uptake During Myocardial Perfusion Imaging

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