99mTc(V)-DMSA seintigraphy in monitoring the response of bone disease to vitamin D3 therapy in renal osteodystrophy

Abstract

Renal osteodystrophy (ROD) is a common and serious complication for uremic patients and patients are treated with 1,25-dihydroxyvitamin D3. The bone scanning agent 99mTc-phosphate has also been used to evaluate in ROD but it is not clear that bone scintigraphy has a role in the follow-up of treatment. In this study 99mTc(V)-DMSA scintigraphy was performed in eleven patients [age 40.7 +/- 17.3 (mean +/- SD) yr] with ROD before and after vitamin D3 therapy. Images were obtained after hemodialysis performed following tracer injection to maintain normal blood levels of the radiopharmaceutical and to reduce soft tissue activity. Lumbar vertebra-to-soft tissue uptake ratios (LUR) were quantified with the planar 99mTc(V)-DMSA images. Alkaline phosphatase and parathyroid hormone levels after treatment had significantly decreased compared with pre-therapy. In all patients there was visually decreased uptake in bone structures after treatment. After treatment the mean LUR ratio was significantly lower than those of before treatment (3.59 +/- 2.63 vs. 1.65 +/- 0.62; p = 0.01). LUR values were correlated with pre-therapy alkaline phosphatase and parathyroid hormone. These findings indicate that 99mTc(V)-DMSA scintigraphy is sensitive in evaluating the response of ROD to vitamin D3 therapy.

Dimercaptosuccinic acid: A multifunctional cost effective agent for imaging and therapy

“…Tc-99m (V) DMSA is a noninvasive tumor cell proliferation marker and may also be used to evaluate the response to radio and chemotherapy, predict patient prognosis and help in management of various tumors and other therapies. [ 51 60 89 90 ]…”

12 Chapters on Nuclear Medicine

“…anterior CT right lateral left lateral Fig. 21. Pathologic uptake of radioiodine in a pulmonary fungus ball.…”

“…Then, the TCP is given by the equation TCP = e −SF = exp −e −αD−βD 2 (19) Whereas NTCP formulation is considered by the interpretation of empirical clinical data, since the organ behavior cannot be easily described by equations, and also the sparing of a normal tissue is not simply linked to the number of surviving cells, but also to the maintenance of its functionality, which depends on the organ architecture. where u = D − TD 50 m • TD 50 (21) when conditions are assumed as in the LQ model for the TCP calculations, m is a dimensionless correction factor and TD 50 is the dose, over all the tumor, for that NTCP is equal to 50%. And it is possible to characterize c(u) as…”

Akut multifokal osteomiyelit: Tc-99m Methylendiphosphanate, Tc-99m HMPAO lökosit ve Tc-99m (V) dimercaptosuccinic acid görüntüleme

“…99m Tc(V) dimercaptosuccinic acid is taken up both by the bone lesions [4][5][6][7] and by some soft tissue infections [7][8][9][10][11]. We present the findings of 99m Tc(V)-DMSA scan as comparison with 99m Tc-MDP bone scintigraphy and 99m Tc-HMPAO-leukocyte imaging in the case with multifocal osteomyelitis.…”