99TcmTechnegas and krypton-81m ventilation scintigraphy: a comparison in known respiratory disease

James, Julie; Lloyd, J. J.; Leahy, B.C.; Church, S.B.; Hardy, C. C.; Shields, R. A.; Prescott, M. C.; Testa, H. J.

doi:10.1259/0007-1285-65-780-1075

Cited by 37 publications

(28 citation statements)

References 18 publications

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“…However, pharmacologically induced bronchoconstriction increases the deposition in central airways, resulting in different distributions of Technegas and 81m Kr (64). Technegas deposition in central airways in patients with chronic obstructive pulmonary disease has also been reported in some clinical studies (21,38). Hinz et al (35) found a good correlation between SPECT measurements of regional ventilation obtained with Technegas and 81m Kr in an animal model of acute lung injury.…”

Section: Active Regulation Of Lung Blood Flowmentioning

confidence: 94%

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Petersson

Sánchez-Crespo²,

Larsson³

et al. 2007

Journal of Applied Physiology

120

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Petersson J, Sá nchez-Crespo A, Larsson SA, Mure M. Physiological imaging of the lung: single-photon-emission computed tomography (SPECT). J Appl Physiol 102: 468 -476, 2007. First published September 21, 2006; doi:10.1152/japplphysiol.00732.2006.-Emission tomography provides threedimensional, quantitative images of the distribution of radiotracers used to mark physiological, metabolic, or pathological processes. Quantitative single photon emission computed tomography (SPECT) requires correction for the imagedegrading effects due to photon attenuation and scatter. Phantom experiments have shown that radioactive concentrations can be assessed within some percentage of the true value when relevant corrections are applied. SPECT is widely spread, and radiotracers are available that are easy to use and comparably inexpensive. Compared with other methods, SPECT suffers from a lower spatial resolution, and the time required for image acquisition is longer than for some alternative methods. In contrast to some other methods, SPECT allows simultaneous imaging of more than one process, e.g., both regional blood flow and ventilation, for the whole lung. SPECT has been used to explore the influence of posture and clinical interventions on the spatial distribution of lung blood flow and ventilation. Lung blood flow is typically imaged using macroaggregates of albumin. Both radioactive gases and particulate aerosols labeled with radioactivity have been used for imaging of regional ventilation. However, all radiotracers are not equally suited for quantitative measurements; all have specific advantages and limitations. With SPECT, both blood flow and ventilation can be marked with radiotracers that remain fixed in the lung tissue, which allows tracer administration during conditions different from those at image registration. All SPECT methods have specific features that result from the used radiotracer, the manner in which it is administered, and how images are registered and analyzed. respiratory physiology; regional blood flow; pulmonary ventilation; pulmonary gas exchange; radionuclide imaging THE NONUNIFORM DISTRIBUTIONS of regional lung blood flow and ventilation were first demonstrated utilizing radioactive tracers (radiotracers) and external scintillation detectors that registered the distribution of radioactivity within the lung (10,14,43,93). Later the development of the gamma camera allowed twodimensional imaging of the distribution of radiotracers (58). In the mid to late 1970s, both single-photon-emission computed tomography (SPECT) and positron emission tomography (PET) were developed, offering three-dimensional images of the in vivo distribution of radioactivity. These techniques can be used to study, for example, the three-dimensional distribution of regional blood flow or regional ventilation with a high spatial resolution. In this article we will first briefly explain the principles and characteristics of the SPECT method and second review studies that exemplifies how SPECT has been used to increase our unde...

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Section: Active Regulation Of Lung Blood Flowmentioning

confidence: 94%

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Petersson

Sánchez-Crespo²,

Larsson³

et al. 2007

Journal of Applied Physiology

120

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“…[29][30][31][32][33] This reflects the fact that Technegas particles are so small that the aerosol closely follows the gas flow down to the alveoli, where they are deposited by diffusion. 31,34 In comparison with liquid radio-aerosols, Technegas has significantly fewer problems of central airway deposition and peripheral "hotspot" formation in patients with obstructive lung disease. Recently, a group of patients routinely admitted for V/Q SPECT and a group of patients with known COPD were studied head to head with [ 99m Tc]-DTPA and Technegas.…”

Section: Comparison Of Ventilation Agentsmentioning

confidence: 99%

Methodology for Ventilation/Perfusion SPECT

Bajc

Neilly

Miniati

et al. 2010

Seminars in Nuclear Medicine

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Ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) is the scintigraphic technique of choice for the diagnosis of pulmonary embolism and many other disorders that affect lung function. Data from recent ventilation studies show that the theoretic advantages of Technegas over radiolabeled liquid aerosols are not restricted to the presence of obstructive lung disease. Radiolabeled macroaggregated human albumin is the imaging agent of choice for perfusion scintigraphy. An optimal combination of nuclide activities and acquisition times for ventilation and perfusion, collimators, and imaging matrix yields an adequate V/Q SPECT study in approximately 20 minutes of imaging time. The recommended protocol based on the patient remaining in an unchanged position during the initial ventilation study and the perfusion study allows presentation of matching ventilation and perfusion slices in all projections as well as in rotating volume images based upon maximum intensity projections. Probabilistic interpretation of V/Q SPECT should be replaced by a holistic interpretation strategy on the basis of all relevant information about the patient and all ventilation/perfusion patterns. PE is diagnosed when there is more than one subsegment showing a V/Q mismatch representing an anatomic lung unit. Apart from pulmonary embolism, other pathologies should be identified and reported, for example, obstructive disease, heart failure, and pneumonia. Pitfalls exist both with respect to imaging technique and scan interpretation. Semin Nucl Med 40: [415][416][417][418][419][420][421][422][423][424][425]

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“…The small particle size implies that they are distributed in the lungs almost like a gas and are deposited in alveoli by diffusion (James et al, 1992). Technegas provides images which are equivalent to those with 81mKr.…”

Section: Ventilationmentioning

confidence: 99%

Quantitative Ventilation/Perfusion Tomography: the Foremost Technique for Pulmonary Embolism Diagnosis

Bajc¹,

Jögi²

2012

Pulmonary Embolism

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99TcmTechnegas and krypton-81m ventilation scintigraphy: a comparison in known respiratory disease

Cited by 37 publications

References 18 publications

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Physiological imaging of the lung: single-photon-emission computed tomography (SPECT)

Methodology for Ventilation/Perfusion SPECT

Quantitative Ventilation/Perfusion Tomography: the Foremost Technique for Pulmonary Embolism Diagnosis

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