2001
DOI: 10.1023/a:1010631800505
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Abstract: Insulinlike growth factor-1 (IGF-1) is an anabolic hormone synthesized by the liver upon stimulation by growth hormone (GH). IGF-1 exerts important effects on renal hemodynamics and renal sodium handling. The bioactivity of this hormone is influenced by its binding proteins (BP) of which IGF-BP3 favors retention in the capillary lumen while IGF-BP1 facilitates the transport to the target tissues. IGF-BP1 modulates the actions of IGF-1 on target cells including renal tubules. Although a number of reports have d… Show more

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Cited by 18 publications
(6 citation statements)
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“…Additionally, patients with cirrhosis had lower circulating IGF1 and IGFBP3 levels than healthy controls ( p < 0.001). This is likely because of reduced secretion of the liver-derived factors IGF1 and IGFBP3 in cirrhosis and HCC patients with chronic liver damage and functional insufficiency [ 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, patients with cirrhosis had lower circulating IGF1 and IGFBP3 levels than healthy controls ( p < 0.001). This is likely because of reduced secretion of the liver-derived factors IGF1 and IGFBP3 in cirrhosis and HCC patients with chronic liver damage and functional insufficiency [ 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…These, in turn, secrete mediators affecting hepatocyte survival, differentiation and function [ 10 , 24 , 30 32 ]. In liver cirrhosis hepatocellular insufficiency causes marked IGF-I deficiency [ 8 , 33 ] and this situation could benefit from hormone replacement therapy. In fact a pilot randomized double-bind clinical trial testing recombinant IGF-I given subcutaneously for 4 months to cirrhotic patients demonstrated amelioration of liver biosynthetic functions with significant improvement of Child-Pugh score [ 34 ].…”
Section: Discussionmentioning
confidence: 99%
“…Among cirrhotics, IGF1 correlated with renal blood flow while a negative correlation was found between IGF1-IGF-BP index and fractional sodium excretion and between IGF-BP1 and urinary sodium excretion. These findings suggest that IGF1 may be related to renal vasodilation and renal sodium retention in cirrhotic patients [18]. …”
Section: Discussionmentioning
confidence: 99%