Untitled

Abstract

Unilateral trauma to the sensorimotor cortex in ambidextrous maternal female rats decreased the resistance of their offspring, as indicated by a reduction in the functional activity of natural killer cells. Offspring rats showed T-cell immunodeficiency regardless of the lateralization of the trauma in their mothers; this was more severe after right-sided trauma (both mature and immature T-lymphocytes were affected). The EMG pattern of evoked responses in offspring rats changed according to the lesions evoked by unilateral trauma in their mothers (in the muscles responsible for postural asymmetry). Cruder movement disturbances were also seen in offspring after right-sided trauma in mothers. Right-sided organic damage to the sensorimotor cortex in mothers evoked marked increases in negative emotionality and decreases in the motivation of orientational-investigative behavior in one-month-old offspring rats in the "open field" test.

Unilateral injury of the sensorimotor cortex of the dominant or subdominant hemisphere in female Wistar rats determines the neurological and immune statuses of their offspring

“…The T-cell immunodeficiency of the young rats affected the subpopulation of immature T lymphocytes (responding to Con A). As demonstrated earlier, left-sided injuries in rats without a distinct functional asymmetry (ambidexters) caused the suppression of the leukocyte migration activity in the presence of PHA in the offspring, whereas right-sided injuries suppressed the lymphocyte responses to both Con A and PHA [3]. In the offspring of ambidexters, irrespective of the location of the injury in their cortex (in the right or left hemisphere), the NK activity was decreased, as it was in the offspring of rats with an injured subdominant hemisphere in our experiments.…”

“…In the offspring of rats with an injured subdominant hemisphere, motor reaction corresponded to a greater extent to the EMG parameters of the offspring of ambidexters with the left-sided injury [3]. Thus, the differences in motor disorders that we observed in the offspring may be determined by both the laterality of the injury and the individual profile of the original asymmetry in the mothers.…”

“…and mm. gastrocnemius) were recorded in the 30-to 35-day-old offspring (i.e., during the postnatal period) according to the method developed earlier [3].…”

“…and mm. gastrocnemius) were recorded in the 30-to 35-day-old offspring (i.e., during the postnatal period) according to the method developed earlier [3].The functional activity of T lymphocytes was determined in one-month-old rats by means of the migration suppression test using peripheral blood leukocytes in flat five-channel capillaries in the presence of 20 µ g/ml PHA (Sigma, United States) or Con A (Sigma, United States) according to Artemova [7]. We used heparinized (50 U/ml) peripheral blood of one-month-old rats.…”

“…The side of cerebral injury determines the pattern of the changes in immune reactivity; e.g., lymphocyte proliferation rate is enhanced in right-sided strokes and suppressed in left-sided ones [2]. Earlier, it was demonstrated that the changes in the motor, behavioral, and immune reactions of the offspring of ambidextrous female rats depended on the laterality of the injury in the brain of the mother [3]. Since animal nervous and humoral responses to injury and stress are determined not only by function laterality, but also by hemispheric dominance [4,5], we searched for immune and motor disorders characteristic of young offspring of "righthanded" and "left-handed" female rats with injuries in the cerebral hemisphere dominant or subdominant with respect to motor preference.…”