Untitled

Genet, Solomon; Kale, R.K.; Baquer, Najma Zaheer

doi:10.1023/a:1016103131408

Cited by 211 publications

(52 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though vanadium may participate in Fenton-like reactions [9], together with the proposed mechanisms of vanadate action that involves its bioreduction and ROS production [15,18,19,40], our results point out to a depression in the overall rate of ROS production. This observation is in good agreement with previous reports showing that vanadate supplementation diminished oxidative stress in certain experimental conditions, such as in rat-induced hepatocarcinogenesis [23] and in rat diabetic tissues [41]. Regarding superoxide anion radical production in mitochondrial fraction, once again it was observed that metavanadate and decavanadate promoted opposite effects.…”

Section: Resultssupporting

confidence: 92%

Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers

Gândara

Soares

Martins

et al. 2005

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

The formation of vanadate oligomeric species is often disregarded in studies on vanadate effects in biological systems, particularly in vivo, even though they may interact with high affinity with many proteins. We report the effects in fish hepatic tissue of an acute intravenous exposure (12, 24 h and 7 days) to two vanadium(V) solutions, metavanadate and decavanadate, containing different vanadate oligomers administered at sub-lethal concentration (5 mM; 1 mg/kg). Decavanadate solution promotes a 5-fold increase (0.135 ± 0.053 lg V À1 dry tissues) in the vanadium content of the mitochondrial fraction 7 days after exposition, whereas no effects were observed after metavanadate solution administration. Reduced glutathione (GSH) levels did not change and the overall reactive oxygen species (ROS) production was decreased by 30% 24 h after decavanadate administration, while for metavanadate, GSH levels increased 35%, the overall ROS production was depressed by 40% and mitochondrial superoxide anion production decreased 45%. Decavanadate intoxication did not induce changes in the rate of lipid peroxidation till 12 h, but later increased 80%, which is similar to the increase observed for metavanadate after 24 h. Decameric vanadate administration clearly induces different effects than the other vanadate oligomeric species, pointing out the importance of taking into account the different vanadate oligomers in the evaluation of vanadium(V) effects in biological systems.

show abstract

Section: Resultssupporting

confidence: 92%

Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers

Gândara

Soares

Martins

et al. 2005

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

show abstract

“…The formation of lipid peroxides was evaluated in the homogenates of the whole kidney. The formation of malondialdehyde (MDA), an end product of fatty acid peroxidation, was measured spectrophotometrically at 532 nm by using a thiobarbituric acid reactive substance mainly by the method of Genet et al [12]. …”

Section: Methodsmentioning

confidence: 99%

Thymoquinone Ameliorates Acute Renal Failure in Gentamicin-Treated Adult Male Rats

et al. 2015

View full text Add to dashboard Cite

Background: Gentamicin (GEN) is considered as a main aminoglycoside antibiotic medicine. The top therapeutic side effect of GEN is nephrotoxicity. The current research was proposed to determine the protective effect of thymoquinone (TQ) on GEN-induced acute renal failure (ARF). Methods: The rats were divided into 6 groups: sham group, control group, GEN-treated group and the TQ-treated groups. At the end of the research period, the serum blood urea nitrogen (BUN) and creatinine (Cr) were measured. The kidneys were then removed for evaluating malondialdehyde (MDA), reduced glutathione (GSH), interleukins IL-6, IL-10, IL-18 and IL-1β, tumor necrosis factor α (TNF-α), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. Results: GEN induced a raise in the levels of serum Cr, BUN and also the levels of MDA, IL-6, IL-18, IL-1β and TNF-α with decease in GSH, SOD, GPx and IL-10 in the kidney (p < 0.05). The data illustrated that the significant elevation in the levels of serum Cr, BUN, MDA, IL-6, IL-18, IL-1β, TNF-α and also the reduction of GSH, SOD, SOD, GPx, IL-10 in the kidney were ameliorated in the TQ-treated groups versus the untreated group, in a dose-dependent manner (p < 0.05). Conclusion: The present investigation proposes that TQ may be ameliorated ARF through modulation of the oxidative stress and inflammatory responses.

show abstract

“…Diabetes is associated with increased oxidative stress as reflected in an increased presence of lipid peroxidation products (Jennings et al 1987;Rosen et al 2001;Siddiqui et al 2005;Genet et al 2002). Like in aging increased oxidative stress appears to be the result of increased formation of ROS, reduction in ROS scavengers or both (Moorthy et al 2005a, b;Baquer et al 1990).…”

Section: Diabetic Neuropathy-peripheral and Central Nervous Systemmentioning

confidence: 99%

“…This process in which glucose is oxidized in the presence of free metal ion, leads to superoxide and hydroxyl radical release, and finally causes protein oxidation (Wolff et al 1991;Wolff and Dean 1987). The activity of ROS scavenger compounds like glutathione, catalase and superoxide dismutase may be affected by diabetes (Wohaieb and Godin 1987;Genet et al 2002). Decrease in ROS scavenging compounds may be due to the direct affect of diabetes and aging on scavenger production or activity, like enhanced protein glycation may be responsible for the reduced enzymatic anti-oxidant activity of superoxide dismutase Mohamad et al 2004).…”

Section: Diabetic Neuropathy-peripheral and Central Nervous Systemmentioning

confidence: 99%

A metabolic and functional overview of brain aging linked to neurological disorders

et al. 2009

Self Cite

View full text Add to dashboard Cite

Close correlations have recently been shown among the late onset complications encountered in diabetes and aging linked to neurobiological disorders. Aging in females and males is considered as the end of natural protection against age related diseases like osteoporosis, coronary heart disease, diabetes, Alzheimer's disease and Parkinson's disease, dementia, cognitive dysfunction and hypernatremia. Beside the sex hormones other hormonal changes are also known to occur during aging and many common problems encountered in the aging process can be related to neuroendocrine phenomena. Diabetes mellitus is associated with moderate cognitive deficits and neurophysiologic and structural changes in the brain, a condition that may be referred to as diabetes encephalopathy; diabetes increases the risk of dementia especially in the elderly. The current view is that the diabetic brain features many symptoms that are best described as accelerated brain aging. This review presents and compares biochemical, physiological, electrophysiological, molecular, and pathological data from neuronal tissue of aging and hormone treated control and diabetic animals to arrive at the similarities among the two naturally occuring physiological conditions. Animal models can make a substantial contribution to understanding of the pathogenesis, which share many features with mechanism underlying brain aging. By studying the pathogenesis, targets for pharmacology can be identified, finally leading to delay or prevention of these complications. Antiaging strategies using hormone therapy, chemical and herbal compounds were carried out for reversal of aging effects. Neuronal markers have been presented in this review and similarities in changes were seen among the aging, diabetes and hormone treated (estrogen, DHEA and insulin) brains from these animals. A close correlation was observed in parameters like oxidative stress, enzyme changes, and pathological changes like lipofuscin accumulation in aging and diabetic brain.

show abstract

Untitled

Cited by 211 publications

References 30 publications

Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers

Vanadate oligomers: In vivo effects in hepatic vanadium accumulation and stress markers

Thymoquinone Ameliorates Acute Renal Failure in Gentamicin-Treated Adult Male Rats

A metabolic and functional overview of brain aging linked to neurological disorders

Contact Info

Product

Resources

About