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Molina, Enrique; Hernandez, A.

doi:10.1023/a:1022868221670

Cited by 119 publications

(61 citation statements)

References 32 publications

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“…Hepatic angiosarcoma arises from vascular endothelial cells within the liver[1]. It is believed that in the past, the malignant transformation of vascular endothelial cells was mediated or triggered by environmental or industrial toxins, such as vinyl chloride, arsenic, and thorium dioxide, however despite tighter regulations of these toxins, there is a still a constant number of reports of angiosarcoma without any such association…”

Section: Introductionmentioning

confidence: 99%

Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome

Wadhwa

Kim

Lin

et al. 2017

WJG

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Hepatic angiosarcoma is a mesenchymal tumor originating from liver sinusoidal endothelial cells. It is an extremely rare malignant neoplasm accounting for less than 1% of primary malignant liver tumors. The deregulated coagulopathy that can be seen in hepatic angiosarcoma fulfills the clinical diagnostic criteria of disseminated intravascular coagulation. However, the mechanism that governs this coagulopathy has been poorly understood. This case report provides histological evidence of the consumption of coagulation factors along with trapped platelets occurring within the tumor, which is the foundation for the concept of Kasabach-Merritt syndrome (KMS). KMS is characterized by thrombocytopenia and hyperconsumption of coagulation factors within a vascular tumor. However, KMS associated with angiosarcoma has not been well recognized. This case report describes, for the first time, the histological evidence of KMS that occurred in an extremely rare mesenchymal malignant tumor of the liver.

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Section: Introductionmentioning

confidence: 99%

Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome

Wadhwa

Kim

Lin

et al. 2017

WJG

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“…Once liver angiosarcoma-induced internal bleeding happens, TAE is usually the first choice to stop the bleeding and to get the patients stable [18,19]. Otherwise, in relatively stable patients, conservative treatment may also work in this situation [2]. However, due to the rare incidence of liver angiosarcoma, how to treat acute bleeding of liver angiosarcoma has not yet reached a definite conclusion at present.…”

Section: Discussionmentioning

confidence: 99%

“…Hepatic angiosarcoma is a very rare disease, accounting for only 2% of primary liver malignancy [1-3]; however, it still ranks as the third place in the list of most common primary liver malignancies [2,3]. Hepatic angiosarcoma originates from endothelial cells and usually presents as an abdominal mass with unspecific symptoms and signs [4], making it difficult to diagnose in the early stage.…”

Section: Introductionmentioning

confidence: 99%

Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture- a case report

et al. 2012

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Liver angiosarcoma is a rare disease, however it still ranks as the third of most common primary liver maligancies. The prognosis of liver angiosarcoma is very poor with almost all patients with this kind of disease die within 2 years after diagnosis. No specific symptoms and signs are closely associated with this disease. Here, we report a case presenting shock status at first due to rupture of liver angiosarcoma- induced internal bleeding. After emergent transarterial embolization (TAE), she received partial hepatectomy two weeks later. 4 months after operation, she is still with a good performance status without obvious recurrence or metastasis identified.

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“…This has been reported in three adult cases that were without evidence of recurrence at 64 months, 38 months, and 10 years. 3 …”

Section: Discussionmentioning

confidence: 99%

Hepatic angiosarcoma five years following spontaneous intraperitoneal bleed of a hepatic mass

et al. 2009

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Primary hepatic angiosarcoma is a rare and rapidly fatal disease. We present the highly unusual identification of this lesion five years after the initial clinical presentation.In 2003, a 32-year-old man presented with abdominal pain, tachycardia, and evidence of hemorrhage. A CT scan showed a hepatic mass with intralesional hemorrhage, intraperitoneal blood, and splenomegaly. The patient was stabilized clinically. Laparoscopic core biopsies demonstrated no malignancy, only findings consistent with an old hemorrhage. Contralateral lobe biopsies revealed normal liver tissue. A metastatic workup was negative and the decision was made to observe the patient clinically with radiographic follow-up, given his suspected portal hypertension based on thrombocytopenia and splenomegaly.Sequential imaging demonstrated a decrease in the size of the mass from 12.0 cm in 2003 to 3.0 cm in 2007. Subsequent newly identified esophageal varices prompted a reevaluation of the case. A repeat biopsy demonstrated a neoplasm of vascular etiology and uncertain malignant potential. By early 2008 the lesion had increased to 4.8 cm and was resected via a left hepatic lobectomy. An extremely vascular lesion with surrounding dense fibrosis was identified and pathologic examination demonstrated a high-grade angiosarcoma.We are unaware of any previous reports suggesting such a prolonged natural history of hepatic angiosarcoma. This case may represent the possibility of malignant transformation of a lower grade vascular neoplasm such as hepatic epithelioid hemangioendothelioma to an angiosarcoma.

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Untitled

Cited by 119 publications

References 32 publications

Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome

Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome

Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture- a case report

Hepatic angiosarcoma five years following spontaneous intraperitoneal bleed of a hepatic mass

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