2018
DOI: 10.22377/ajp.v12i03.2568
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Abstract: Introduction: The aim of the present research work was to develop asenapine maleate (AM)-loaded solid lipid nanoparticles (AM-SLN) for the enhancement of oral bioavailability of drug and delivery to the brain. Materials and Methods: A 3 2 factorial design was used for the development and optimization of AM-SLN. Two independent variables, drug:lipid ratio (X 1) and number of homogenization cycles (X 2), were selected, while particle size and entrapment efficiency were selected as response variables. The optimiz… Show more

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