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Abstract

The present study was aimed to formulate and evaluate floating microspheres of Baclofen. The research work's objective was to retain Baclofen in the stomach for a prolonged period of time, which has absorption window in the upper gastrointestinal tract. The microspheres were prepared by solvent evaporation technique. A 3 2 full factorial was applied to investigate the combined effect of the two independent variables, i.e., the concentration of Eudragit RL100 (X1) and concentration of Eudragit RS 100 (X2) on the dependent variables particle size (Y 1 ), percentage drug entrapment efficiency (Y 2 ), percentage buoyancy (Y3), in-vitro drug release at 1 h (Y4), in-vitro drug release at 6 h (Y 5 ). Results of the multiple regression analysis revealed that in-vitro drug release decreased and particle size, percentage drug entrapment efficiency, percentage buoyancy was increased with increasing the concentration of Eudragit RL100 and Eudragit RS100. The optimized formulation has a particle size of 115.96 µm, percentage drug entrapment of 90.06%, and buoyancy of 90.76%. In-vitro drug release of Baclofen floating microspheres showed a sustained release up to 24 h. The floating microspheres were free-flowing, porous, and almost spherical in shape. The in-vitro drug release kinetics studies revealed that the Higuchi model was followed by the formulation and drug release by fickian diffusion mechanism.