Background: Chronic kidney disease is characterized by kidney impairment and a glomerular filtration rate lower than sixty milliliters per minute for more than three months. Furthermore, hemodialysis patients are at significant risk for a range of problems, which might result from kidney disorders or the hemodialysis operations themselves. The purpose of this study is to assess hemodialysis patients' knowledge and attitudes toward personalized care.Methods: A four-month cross-sectional study was conducted. The nonprobability convenient method of sampling was used, and the sample size was 250 participants (dialysis patients). After removing individuals who did not respond to the survey), our final number of participants was 170 hemodialyses (HD) individuals, and the information was obtained utilizing an online/offline survey with a questionnaire. Results: This study included an overall sample of 170 people ranging in age from 18 to 85 years, with 62 (36.5%) females and 108 (63.5%) males. Diabetes mellitus was found to be the disease with the greatest incidence among the group of individuals (67.41%), followed by hypertension 50 (29.4%), cardiovascular disease 25 (14.7%), hepatic disease 10 (5.88%), and most commonly used treatment in our study was antidiabetic medications. Conclusion: When it came to renal diet, drugs, and modifications to their lifestyles, the individuals in this study exhibited low Knowledge, Attitude, and Self-Care. Our research showed that male individuals knew more about the side effects of hemodialysis than female subjects. The maintenance hemodialysis patients' comprehension and practice were enhanced by receiving guidance on diet, medication, and lifestyle adjustments.