Untitled

Abstract

Genomic rearrangements are hot topics for research and debates due to their complex natures as well as significant health impact in either congenital or malignant disorders. In order to explain the mechanisms responsible for their generation, models have been proposed to the literature with the most well recognized of them the non-allelic homologous recombination (NAHR), micro homology-mediated break induced recombination and fork stalling and template switching, each associated with own limitations. In an attempt to address the limitations associated with the previous models, in the current study a new model is represented and substantiated by describing some of the most frequently observed recurrent rearrangements that have been reported to the literature.