1997
DOI: 10.1023/a:1026409326690
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Abstract: The utility of quality of life (QOL) as an evaluative tool in clinical psychiatric research and drug trials could be enhanced by developing appropriate conceptual models of QOL, specific for psychiatric disorders. In our proposed model, QOL of individuals maintained on antipsychotic drug therapy for schizophrenia, is viewed as the subject's perception of the outcome of an interaction between severity of psychotic symptoms, side-effects including subjective responses to antipsychotic drugs, and the level of psy… Show more

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Cited by 124 publications
(12 citation statements)
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“…BASIS (daily living and role functioning), with a β = −0.537 (p < .0001), was observed to have an extremely strong impact on QOL (total). Award et al [23] cited severity of psychiatric symptoms, side effects, and level of psychosocial functioning as the 3 most important determinants of schizophrenic patients’ QOL. In a pilot study, Lauer [24] reported observing a significant negative correlation between subjective QOL and acute psychiatric symptoms (Brief Psychiatric Rating Scale).…”
Section: Discussionmentioning
confidence: 99%
“…BASIS (daily living and role functioning), with a β = −0.537 (p < .0001), was observed to have an extremely strong impact on QOL (total). Award et al [23] cited severity of psychiatric symptoms, side effects, and level of psychosocial functioning as the 3 most important determinants of schizophrenic patients’ QOL. In a pilot study, Lauer [24] reported observing a significant negative correlation between subjective QOL and acute psychiatric symptoms (Brief Psychiatric Rating Scale).…”
Section: Discussionmentioning
confidence: 99%
“…Ritsner et al used the Montgomery-Asberg Depression Rating Scale (MADRS), the Talbieh Brief Distress Inventory (TBDI), the Abnormal Involuntary Movement Scale (AIMS), and the Quality of Life Enjoyment and Satisfaction Questionnaire in schizophrenia patients and reported that the depression score on the TBDI and the score on the AIMS were predictors of poor QOL [35]. Awad et al used the PANSS, the Hillside Akathisia scale, and the Drug Attitude Inventory to show that subjective QOL is greatly influenced by psychopathology, akathisia, and patients' subjective tolerance of medications, and concluded that effort should be directed toward effective control of psychotic symptoms and minimizing the side effects of antipsychotic drugs to improve the QOL of patients with schizophrenia [24]. Therefore, we thought that patients with extrapyramidal symptoms induced by typical antipsychotics have more subjective discomfort with respect to their symptoms and side effects than patients receiving atypical antipsychotics.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have suggested that depressed mood may be the most important determinant of QOL [17][22]. Other studies have reported that positive symptoms [23] or akathisia symptoms, as well as the total severity of psychopathology [24], help predict subjective QOL. Regarding the influence of antipsychotics on QOL, Mortimer et al reported that QOL is genuinely superior with atypical agents even allowing for the confounding effects of differential prescribing habits [25].…”
Section: Introductionmentioning
confidence: 99%
“…Studies addressing QoL for patients with schizophrenia and other severe mental illnesses have identified a number of important influential factors, such as social support [5], unmet needs, [6] and medication side effects [7]. …”
Section: Introductionmentioning
confidence: 99%