Untitled

Abstract

Glyprolines, short proline-containing peptides (Pro-Gly-Pro, Pro-Gly, and Gly-Pro) in concentrations of 10(-8)-10(-4) M decreased norepinephrine tone of the isolated rat aortic rings. The vasodilatory effect of Pro-Gly-Pro and Pro-Gly was associated with NO release from endotheliocytes, while Gly-Pro directly affected vascular smooth muscle cells.

The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis

“…They maintain homeostasis in the gastric mucosa under ulcerogenic conditions, prevent microcirculatory disturbances [2], inhibit thrombus formation [8], and are involved in the regulation of vascular tone [1].…”

C-Terminal Pro-Gly-Pro Tripeptide in Contrast to Full-Length Neuropeptide Semax Exhibits No Neuroprotective Effect in Experimental Cerebral Ischemia

“…Semax and PGP possess antiulcerogenic effect preventing the development of experimental gastric ulcers and promoting ulcer healing in experimental animals and patients [1,5,6,9]. The protective effect of PGP in gastric ulcer is attributed to its capacity to correct the bloodflow in the gastric mucosa and to relax blood vessels [3,9]. We detected no neuroprotective effect of PGP in rats with cerebral ischemia: symptoms of ND progressed similarly in experimental rats injected with PGP and in controls injected with saline.…”

Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection

“…The behavioral parameters in the hole-board and elevated plus-maze tests were evaluated 1 h after injection of CCK-4 [2]. The time of observation was 3 min in each test.…”

“…Short di-and tripeptides containing glycine and proline can cross the blood-brain barrier [3,4] and produce protective and therapeutic effects in behavioral disturbances caused by physical strain in rats [1,2,6].…”

“…Preliminary intraperitoneal or intranasal administration of these peptides in doses of 3.7 and 37 μmol/kg considerably prevented the development of post-stress behavioral disturbances, while administration of these peptides against the background of developed post-stress behavioral disturbances almost completely abolished them [1,2].…”