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Abstract

Background: The objective of this study was to assess drug therapy problems (DTPs) and their predictors among hypertensive patients on follow up at Dil-Chora Referral Hospital, Ethiopia. Methods: Hospital based cross-sectional study involving medical record review was conducted from February-to-April 2015 using a structured questionnaire and this was complemented by a face-to-face interview. Adult hypertensive patients aged ≥18 years who were on follow-up for at least 3-months were enrolled in the study using a convenient sampling method. Data analysis was done using SPSS software version 16.0. Multiple logistic regressions were fitted and odds ratios with 95%CI were calculated to identify factors associated with DTPs. Results: The study included 271 hypertensive patients. Mean age was 57.73±12.13. One hundred sixty three (60.1%) were females. More than half of the respondents (50.6%) had comorbid condition and diabetes was the most common. More than 71% of patients were found to have at least one DTP and the mean number of DTPs per patient was 1.39±1.28. Need additional drug therapy(62.4%) and non-adherence(32.8%) were the two most common DTPs. Presence of comorbidity (AOR=5.74, 95%CI; 2.49-13.00), taking ≥3 medications per day (AOR=7.04, 95%CI; 2.33-21.25), and uncontrolled blood pressure (BP) (AOR=7.68, 95%CI; 3.70-15.90) were factors associated with DTPs. Conclusions: DTPs are common among hypertensive patients on follow up and the most common were need additional drug therapy and non-adherence to medications. Pharmacist interventions in drug therapy would help physicians in early identification and prevention of DTPs so that a joint effort between physicians and pharmacists should be made.

Assessment of Drug Therapy Problems Among Type 2 Diabetes Patients with Hypertension Comorbidity in Indonesia

“…Potential adverse drug reaction event in the combination of medications treatment higher than single medication treatment. This study contrasting to another study who reported the most common drug therapy problems was the need for additional drug therapy (Yimama et al, 2018;Argaw et al, 2019;Hussen et al, 2017). Percentage of DTP events in this study is visualized in Figure 1.…”

“…Several studies in some countries such as Malaysia, Ethiopia, and Nigeria about DTPs in T2DM with hypertension have shown that each diabetes patients experienced at least one of drug therapy problems (Huri & Wee, 2013;Yimama et al, 2018;Argaw et al, 2019;Hussen & Daba, 2017;Ayele et al, 2018;Ogbonna et al, 2014). Drug therapy problems may lead to elevating morbidity, disability, mortality, health care cost, low adherence, and prolonged hospitalization (Nivya et al, 2015;Claydon-Platt et al, 2012).…”