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doi:10.13040/ijpsr.0975-8232.7(10).4134-39

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“…These can include tissue necrosis with wound exposure and especially bacterial infections, arising from not only the external environment but also adjacent structures such as the sinuses, nasopharynges and oral cavity [ 13 ]. The inflammatory process activates the host defence system in an overshooting manner, with increased production of cytokines progressing towards alveolar bone resorption and irreversible bone loss [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Minocycline Hydrochloride as an Adjuvant Therapy for a Guided Bone Augmentation Procedure in The Rat Calvarium

et al. 2023

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This in vivo study reports the influence of minocycline-HCl administration on extra-skeletal bone generation in a Guided Bone Augmentation model, utilizing titanium caps placed on the intact as well as perforated calvaria of rats. The test group was administered 0.5 mg/mL minocycline-HCl with the drinking water, and the amount of bone tissue in the caps was quantified at three time points (4, 8 and 16 weeks). A continuously increased tissue fill was observed in all groups over time. The administration of minocycline-HCl as well as perforation of the calvaria increased this effect, especially with regard to mineralization. The strongest tissue augmentation, with 1.8 times that of the untreated control group, and, at the same time, the most mineralized tissue (2.3× over untreated control), was produced in the combination of both treatments, indicating that systemic administration of minocycline-HCl has an accelerating and enhancing effect on vertical bone augmentation.

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Section: Introductionmentioning

confidence: 99%