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Shikhaliev, Kh. S.; Leshcheva, E. V.; Solov’ev, A. S.

doi:10.1023/a:1023914810461

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Cited by 5 publications

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Bischler Reaction

2010

Comprehensive Organic Name Reactions and Reagents

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The reaction for preparation of 2‐substituted indoles by heating a‐haloketone, a‐hydroxyketone, or a‐anilinoketone with excess aniline via the cyclization of a 2‐arylaminoketone intermediate is known as Bischler reaction. This reaction has application for the preparation of a number of tetrahydrocarbazoles from anilines and 2‐chlorocyclohexanones and N‐substituted indole‐3‐acetic acids and acetamides. Besides this the reaction can be applied to the synthesis of benzofuran and benzothiophene.

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Bischler Reaction

2010

Comprehensive Organic Name Reactions and Reagents

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2,2,4‐Trimethylhydroquinolines in the Bischler—Melau Reaction.

2003

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Ultrasound mediated synthesis of 6-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinoline derivatives and their pharmacological evaluation

Rao¹,

Haritha

Chandrasekhar

et al. 2019

Arabian Journal of Chemistry

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Designed as potential cytotoxic agents a series of 6-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinoline derivatives were synthesized by using a Bischler type reaction. The methodology involved the cyclodehydration of 2-(3,4-dihydroquinolin-1(2H)-yl)-1-alkyl/aryl ethanones in the presence of p-TSA under ultrasound irradiation. A number of compounds were prepared using this methodology and tested for their in vitro anti-proliferative properties against cancer (leukemia) and non-cancerous cell lines. Some of the compounds showed promising and selective cytotoxic effects toward leukemia cells. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Cited by 5 publications

References 2 publications

Bischler Reaction

Bischler Reaction

2,2,4‐Trimethylhydroquinolines in the Bischler—Melau Reaction.

Ultrasound mediated synthesis of 6-substituted 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinoline derivatives and their pharmacological evaluation

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