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Rao, K. Chandrasekhara; Divakar, Soundar; Rao, A. G. Appu; Karanth, N. G.; Suneetha, W. Jessie; Krishnakantha, T. P.; Sattur, A. P.

doi:10.1023/a:1021125731940

Cited by 7 publications

(5 citation statements)

References 21 publications

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“…Similarly, the yellow pigment obtained from Aspergillus niger demonstrated enzyme (15-Lipoxygenase) inhibitory activity and human platelet aggregation. 15 Overall very few reports are on yellow pigment production of Aspergillus family and no reports are available on the application of this pigment for textile coloring. In the present study, the yellow pigment extracted from Aspergillus family has unique characteristic features and the physiochemical properties of the yellow pigment were shown in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…13 The yellow pigment production from Phellinus pini reported for its antifungal activity reported during 1996. 14 Rao et al 15 reported the enzyme (15-Lipoxygenase) inhibitory and human platelet aggregation activity of asperenone isolated from Aspergillus niger during 2002. 15 All the summarized information suggested that no reports are available on the application of Asperyellone after the year 2002.…”

Section: Introductionmentioning

confidence: 99%

“…14 Rao et al 15 reported the enzyme (15-Lipoxygenase) inhibitory and human platelet aggregation activity of asperenone isolated from Aspergillus niger during 2002. 15 All the summarized information suggested that no reports are available on the application of Asperyellone after the year 2002. In the preliminary study, the compound showed very good coloring property, research initiatives are made to study the textile dyeing property of Asperyellone from A. niger and this is the first report on the textile dyeing property of Asperyellone.…”

Section: Introductionmentioning

confidence: 99%

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Asperyellone – a suitable coloring agent for protein based textile fabrics: an approach on production, characterization and application

Gnanamani¹,

S²,

Sk³

et al. 2019

JTEFT

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Color is the first thing which is perceived by the senses. Natural colorants are extremely safe because of its added advantages. The present study describes extraction, characterization and application of a yellow pigment from Aspergillus species, strains AN01 and explores its wider applications. The chosen strain isolated from the soil displayed an extracellular yellow pigment production when grown at specific nutrient and growth conditions. The yellow color pigmented solution free from spores extracted, concentrated, purified and subjected to characterization using UV, FT-IR, DSC, TGA, GC-MS and NMR analyses. From the results the yellow pigment is identified as Asperyellone. Coloring efficacy of the yellow pigment on silk, cotton, synthetic and wool fabrics demonstrates appreciable color uptake by the materials. Increased dye uptake is observed in the protein fibers and polypropylene. The high K/S values corroborate substantiates the preference of Asperyellone pigment to proteins than other natural or synthetic fabrics. The fastness of the pigment on the various substrates is found to be good except to the light fastness. Additional molecular docking studies with silk protein and Asperyellone display the interaction and appreciable binding energy. The above results authenticate the suitability of yellow pigment to enhance the organoleptic property of silk, which ultimately will improve the export value at appreciable level.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Asperyellone – a suitable coloring agent for protein based textile fabrics: an approach on production, characterization and application

Gnanamani¹,

S²,

Sk³

et al. 2019

JTEFT

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“…Lipoxygenases are a class of non-heme, iron-containing enzymes that catalyze the incorporation of molecular oxygen into 1,4,- cis,cis -pentadiene-containing fatty acids (e.g. linoleic and arachidonic acids) to form hydroperoxide products. − Lipoxygenases are the first committed step in a cascade of metabolic pathways that are implicated in the onset of cancers, asthma, and heart disease, making them candidates for inhibitory pharmaceutical therapy. − The human isozymes, 5-, 12-, and 15-lipoxygenase, are associated with different disease states, which suggests that selective inhibition may be important in targeting them for therapeutic purposes. − Recent discovery efforts of lipoxygenase inhibitors − have focused especially on structure−activity relationships − and natural product isolation. − In a very recent report, pharmacophore virtual screening methods have yielded novel inhibitors with selectivity for rabbit 15-lipoxygenase . One selective human 5-lipoxygenase inhibitor, Zileuton, has been approved by the FDA for the treatment of asthma …”

Section: Introductionmentioning

confidence: 99%

Novel Human Lipoxygenase Inhibitors Discovered Using Virtual Screening with Homology Models

et al. 2006

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We report the discovery of new, low micromolar, small molecule inhibitors of human platelet-type 12- and reticulocyte 15-lipoxygenase-1 (12-hLO and 15-hLO) using structure-based methods. Specifically, we created homology models of 12-hLO and 15-hLO, based on the structure of rabbit 15-lipoxygenase, for in silico screening of a large compound library followed by in vitro screening of 20 top scoring molecules. Eight of these compounds inhibited either 12- or 15-human lipoxygenase with lower than 100 microM affinity. Of these, we obtained IC50 values for the three best inhibitors, all of which displayed low micromolar inhibition. One compound showed specificity for 15-hLO versus 12-hLO; however, a selective inhibitor for 12-hLO was not identified. As a control we screened 20 randomly selected compounds, of which none showed low micromolar inhibition. The new low-micromolar inhibitors appear to be suitable as leads for further inhibitor development efforts against 12-hLO and 15-hLO, based on the fact their size and chemical properties are appropriate to classify them as drug-like compounds. The models of these protein-inhibitor complexes suggest strategies for future development of selective lipoxygenase inhibitors.

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“…3,4 It exhibited an inhibitor of soybean 15-lipoxygenase and human platelet aggregation. 5 Spectroscopic studies of (1) have indicated that the pigment is a substituted phenyltridecapentaene-3-one, with methyl group located somewhere on the side-chain. In 1996, the location of the methyl group was suggested using NMR spectroscopy.…”

mentioning

confidence: 99%

Isolation and Crystal Structure of all-trans (E)-8-Methyl-13-phenyltrideca-4,6,8,10,12-pentaen-3-one

Abdelfattah

2008

Anal. Sci. X

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In our screening for bioactive secondary metabolites from microorganisms, 1 fungal contamination of the S. argillaceus M7OII 2 was found to produce an intensive non-polar yellow pigment. Working up of the strain resulted in the isolation of all-trans (E)-8-methyl-13-phenyltrideca-4,6,8,10,12-pentaen-3-one, also called asperenone, (1). A literature search revealed that (1) has been isolated from both Aspergillus awamori and niger. 3,4 It exhibited an inhibitor of soybean 15-lipoxygenase and human platelet aggregation.5 Spectroscopic studies of (1) have indicated that the pigment is a substituted phenyltridecapentaene-3-one, with methyl group located somewhere on the side-chain. In 1996, the location of the methyl group was suggested using NMR spectroscopy. 6In addition, the stereochemistry was assumed to be all-trans (E) based on the relative extinction coefficients of bands associated with the vibrational fine structure of the absorbing molecule in its visible and UV spectra. In order to obtain detailed information on the structural conformation of 1, and to confirm the geometry, an X-ray structure determination was carried out.The fungal contamination of the S. argillaceus M7OII was isolated and purified on agar plates with the M2 medium (glucose 4 g/l, malt extract 10 g/l and yeast extract 4 g/l) at 28˚C for 48 -72 h, where it grew with a thick greenish aerial mycelium and yellow agar coloration.Thirty 250 cm 3 Erlenmeyer flasks, each containing 100 mL of M2 medium, were inoculated with a well-grown agar subculture and incubated with 110 rpm at 28˚C for 3 days. The yellow culture broth was centrifuged at 4200 rpm for 20 min. The resulting broth and mycelial cake were extracted three times with ethyl acetate. Since the extracts exhibited a similar composition by TLC, they were combined and evaporated to dryness under a vacuum at 30˚C. The crude residue (ca. 0.9 g) was pre-separated into two fractions on Sephadex LH-20 (4 ¥ 120 cm, CH2Cl2/50% MeOH). The first fraction (145 mg) containing the yellow pigment 1 was finally purified by preparative HPLC (column, mBondapak C18 radial compression cartridge, PrepPak cartridge, 19 K 150 mm, Waters; eluent water and acetonitrile (gradient from 35 to 100% in 30 min); flow rate, 7 mL/min -1 ) to give 6.9 mg of 1. X-ray

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Cited by 7 publications

References 21 publications

Asperyellone – a suitable coloring agent for protein based textile fabrics: an approach on production, characterization and application

Asperyellone – a suitable coloring agent for protein based textile fabrics: an approach on production, characterization and application

Novel Human Lipoxygenase Inhibitors Discovered Using Virtual Screening with Homology Models

Isolation and Crystal Structure of all-trans (E)-8-Methyl-13-phenyltrideca-4,6,8,10,12-pentaen-3-one

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