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Clément, Jérôme; Manero, J. M.; Ja, Planell; Avila, G.; Martı́nez, S.

doi:10.1023/a:1008927222081

Cited by 51 publications

(10 citation statements)

References 5 publications

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“…This is due to the expected strong ionic cross-linking in the phosphate network structure from the inclusion of Mg 2+ , Zn 2+ and Ca 2+ cations and their respective charge-to-size ratios (0.0232, 0.0227 and 0.0175). The network structure would then be more capable of suppressing the onset of crystallisation in line with previous results [20, 33, 36, 37]. However, previous studies have also shown that increased network stability is associated with a higher T g due to the increased energy required to fracture the structural bonds that contradicts the comparatively low T g found in these results.…”

Section: Discussionsupporting

confidence: 82%

“…This indicated the precipitation of compounds out of solution due to the super saturated conditions of the media and the ions released during glass fibre dissolution [36]. The handling of fibres also became increasingly difficult after 48 h due to increasing brittleness.…”

Section: Resultsmentioning

confidence: 99%

“…This could be due to the in vivo circulation of the extracellular fluid helping to maintain a physiological pH in the surrounding environment and allowing for apatite nucleation on the glass surface compared to the static environment encountered in vitro. Consequently the fibres may also be capable of displaying similar behaviour in vivo through improved pH regulation [36, 43, 72, 73]. However, it should also be considered that when applied as a composite reinforcing agent, the altered fibre dissolution rates as well as the large volume fractions of fibres may lead to the development of alternate phases when such composites are immersed in c-SBF.…”

Section: Discussionmentioning

confidence: 99%

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Characterisation of CorGlaes® Pure 107 fibres for biomedical applications

Colquhoun

Gadegaard

Healy³

et al. 2016

J Mater Sci: Mater Med

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A degradable ultraphosphate (55 mol % P2O5) quinternary phosphate glass composition has been characterised in terms of its chemical, mechanical and degradation properties both as a bulk material and after drawing into fibres. This glass formulation displayed a large processing window simplifying fibre drawing. The fibres displayed stiffness and strength of 65.5 ± 20.8 GPa and 426±143 MPa. While amorphous discs of the glass displayed a linear dissolution rate of 0.004 mg cm−2 h−1 at 37 °C, in a static solution with a reduction in media pH. Once drawn into fibres, the dissolution process dropped the pH to <2 in distilled water, phosphate buffer saline and corrected-simulated body fluid, displaying an autocatalytic effect with >90 % mass loss in 4 days, about seven times faster than anticipated for this solution rate. Only cell culture media was able to buffer the pH taking over a week for full fibre dissolution, however, still four times faster dissolution rate than as a bulk material. However, at early times the development of a HCA layer was seen indicating potential bioactivity. Thus, although initial analysis indicated potential orthopaedic implant applications, autocatalysis leads to accelerating degradation in vitro.

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Section: Discussionsupporting

confidence: 82%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Characterisation of CorGlaes® Pure 107 fibres for biomedical applications

Colquhoun

Gadegaard

Healy³

et al. 2016

J Mater Sci: Mater Med

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“…P is a macronutrient essential for physiological functions such as skeletal development, mineral metabolism and cell signaling [ 27 , 28 ], and dietary intake of B plays important roles in bone formation and maintenance [ [29] , [30] , [31] ]. PBG have been formed with good bioactivity and biocompatibility and have been proposed for bone repair and reconstruction [ 32 , 33 ]. Similarly, BBG have been shown to promote the osteogenic differentiation of human mesenchymal stem cells in vitro [ 39 ], used to treat osteomyelitis in a rabbit model in vivo [ 34 ], and employed to repair calvarial defects in mice [ 42 , 43 ].…”

Section: Introdctionmentioning

confidence: 99%

A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair

et al. 2019

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Objectives Wnt/β-catenin signalling plays important roles in regeneration, particularly in hard tissues such as bone and teeth, and can be regulated by small molecule antagonists of glycogen synthase kinase 3 (GSK3); however, small molecules can be difficult to deliver clinically. Lithium (Li) is also a GSK3 antagonist and can be incorporated into bioactive glasses (BG), which can be used clinically in dental and bone repair applications and tuned to quickly release their constituent ions. Methods Here, we created phosphate (P)- and borate (B)-based BG that also contained Li (LiPBG and LiBBG) and examined their ion release kinetics and the toxicity of their dissolution ions on mouse 17IA4 dental pulp cells. Results We found that although LiPBG and LiBBG can both quickly release Li at concentrations known to regulate Wnt/β-catenin signalling, the P and B ions they concomitantly release are highly toxic to cells. Only when relatively low concentrations of LiPBG and LiBBG were placed in cell culture medium were their dissolution products non-toxic. However, at these concentrations, LiPBG and LiBBG’s ability to regulate Wnt/β-catenin signalling was limited. Significance These data suggest that identifying a BG composition that can both quickly deliver high concentrations of Li and is non-toxic remains a challenge.

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“…13,14 Thus, phosphate glasses have been studied in various biomedical applications, especially for use in bone repair and reconstruction. 15 Apart from their biological properties, phosphate glasses are also of great interest due to their easy processing, excellent thermo-mechanical and chemical properties, homogeneity, good thermal stability, and excellent optical properties, such as high transparency in the UV-Visible-Near-Infrared (UV-Vis-NIR) region. [16][17][18][19][20] Besides, phosphate glasses allow high rare-earth (RE) ions solubility.…”

mentioning

confidence: 99%

Design, processing, and characterization of an optical core‐bioactive clad phosphate fiber for biomedical applications

et al. 2019

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The aim of this study was to fabricate a bioactive optical fiber able to monitor “in situ” its reaction with the body through changes in its optical properties. Core and cladding preforms were prepared with the composition (97.25*(0.50P2O5‐0.40SrO‐0.10Na2O)‐2.5ZnO‐0.25Er2O3) and (98.25*(0.50P2O5‐0.40SrO‐0.10Na2O)‐1.75ZnO) (in mol%), respectively, and successfully drawn into a multimode core/clad optical fiber. Optical and near‐Infrared images assessed the proper light guiding properties of the fiber. The fibers favor the precipitation of a Ca‐P reactive layer at its surface concomitant with a reduction in the fiber diameter, when immersed in SBF, often assigned as a sign of bioactivity. It is clearly shown here that the bio‐response of the fiber upon immersion in SBF can be tracked from the decrease in the intensity of the Er3+ ions emission at 1.5 µm. This confirms that the newly developed optical fiber, which combines good optical properties with a suitable bioactive behavior, is a promising platform for the development of novel biomedical devices for biophotonic and photomedical applications. Finally, the successful splicing of the newly developed fiber with commercial optical fibers was an evidence of the possibility to integrate the newly developed phosphate fiber within existing components used in the field of biomedicine.

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Untitled

Cited by 51 publications

References 5 publications

Characterisation of CorGlaes® Pure 107 fibres for biomedical applications

Characterisation of CorGlaes® Pure 107 fibres for biomedical applications

A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair

Design, processing, and characterization of an optical core‐bioactive clad phosphate fiber for biomedical applications

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