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Abstract

ABSTRACT:The roots of Landolphia heudelotti are employed in traditional medicine for the treatment of a plethora of ailments. In this study, the antioxidant activity and bioactive constituents of the methanol root extract were investigated. Fourteen known compounds including a lignan, neolignans, sesquilignans, a coumarin and an aromadendrane sesquiterpene were isolated from the root extract. The structure elucidation of compounds was performed based on mass spectral and NMR spectroscopic data and by comparison with literature. The crude extract had a high total antioxidant Capacity of 108.8 ± 14.52 mg/g of dried extract (ascorbic acid equivalent) and also demonstrated significant DPPH free radical scavenging activity (IC 50 = 6.956 ± 0.8121 µg/mL). The extract also had a total phenolic content of 98.14 ± 14.70 mg/g of dried extract (tannic acid equivalent). The results of this study have given scientific credence to the use of L. heudelotti roots in traditional medicine. This is the first report of these phyto-constituents from L. heudelotti.