Abstract:Cyclosporine A (CsA) is an immunosuppressant agent. Two niosomal formulations of CsA, F TS and F SB were formulated. Both formulations were studied in terms of size, polydispersity index (PDI), morphology and entrapment efficacy etc. Niosomal formulations F TS and F SB and plain aqueous dispersion were given to three assemblies of Albino rabbits (n=8 per group). CsA levels in plasma were determined at appropriate time intervals and pharmacokinetic parameters were evaluated. The percentage entrapment efficienci… Show more
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