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Abstract

Aim: Obesity is generally linked to complications in lipid metabolism and oxidative stress. The aim of this study was to compare the effect of a proprietary extract of Cissus quadrangularis (CQR-300) to that of a proprietary formulation containing CQR-300 (CORE) on weight, blood lipids, and oxidative stress in overweight and obese people. Methods:The first part of the study investigated the in vitro antioxidant properties of CQR-300 and CORE using 3 different methods, while the second part of the study was a double-blind placebo controlled design, involving initially 168 overweight and obese persons (38.7% males; 61.3% females; ages 19-54), of whom 153 completed the study. All participants received two daily doses of CQR-300, CORE, or placebo and were encouraged to maintain their normal levels of physical activity. Anthropometric measurements and blood sampling were done at the beginning and end of the study period.Results: CQR-300 as well as CORE exhibited antioxidant properties in vitro. They also acted as in vivo antioxidants, bringing about significant (p < 0.001) reductions in plasma TBARS and carbonyls. Both CQR-300 and CORE also brought about significant reductions in weight, body fat, total cholesterol, LDL-cholesterol, triglycerides, and fasting blood glucose levels over the respective study periods. These changes were accompanied by a significant increase in HDL-cholesterol levels, plasma 5-HT, and creatinine.Conclusion: CQR-300 (300 mg daily) and CORE (1028 mg daily) brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors. The increase in plasma 5-HT and creatinine for both groups hypothesizes a mechanism of controlling appetite and promoting the increase of lean muscle mass by Cissus quadrangularis, thereby supporting the clinical data for weight loss and improving cardiovascular health.

Impact of chromium histidinate on high fat diet induced obesity in rats

“…Nuclear factor-kappa B in most cells is bound with an inhibitory protein of nuclear factor-κB (IκB) to form a latent, inactive transcription factor in the cytoplasm. In the case of oxidative stress and various cytokines, NF-κB is released rapidly from IκB to activate the gene expression of several cytokines, chemotactic and matrix proteins involved in inflammation, immunological responses and/or proliferation [8,34]. The results have shown that consumption of a HFD enhanced NF-κB p65 subunit activation in rat liver, which supports our observation of high fat diet-induced oxidative stress.…”

Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

“…Eighteen randomized controlled trials (RCTs) (sample size > 50 cases) [16–33] published from 2007 to 2017 were included. Studies of herbal medicine interventions for obesity that had no obvious effects were excluded.…”

“…The studies were performed in many different populations. Eleven studies [16–18, 20, 21, 23, 25, 28–30, 33] mentioned complications, including hypertension, impaired glucose tolerance, spleen hypofunction, excessive sweating, nonalcoholic fatty liver disease, hyperlipidemia, and metabolic syndrome. Of the 18 studies, 6 were completed by Chinese researchers, and the remaining 12 were from Japan, Australia, Canada, USA, Russia, France, Indonesia, Korea, Indian, Thailand, and Italy.…”

Study on the interaction between theasinesin and human serum albumin by fluorescence spectroscopy

“…1; formula: C 44 H 34 O 22 ; molecular weight: 914.76) and is the main active component of tea polyphenols. Several studies indicate that tea polyphenols present extensive pharmacological activity, such as antibacterial [1], antitoxin [2], antiviral [3,4], antiradiation [5], anticarcinogenic [6], scavenging of free radicals [7], antioxidant [8], anti-cardiovascular disease [9], reducing weight [10] and strengthening immunity [11,12]. However, transportation and metabolism of theasinesin are still little understood.…”