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Abstract

Background: Solubility is an important boundary to obtaining the needed drug concentrations in systemic circulation for pharmacological response to be shown. In today"s time, poor water solubility is the crucial issue faced with developing new chemical entities. Objective: Cefixime trihydrate (CT) is an oral third-generation cephalosporin antibiotic used to treat bacterial diseases. It has an oral bioavailability of 40-50% and belongs to the BCS class-IV. This study aims to boost the solubility of poorly aqueous soluble anti-bacterial drug cefixime trihydrate (CT) by the hydrotropic solubilization technique. Methods: Hydrotropy is one of the solubility improvement techniques that enhance the solubility to many folds with hydrotropes. Sodium benzoate (SB) and piperazine (PP) are the hydrotropes that were selected for the preparation of solid dispersion to improve the solubility of cefixime trihydrate. Thus, prepared solid dispersions were evaluated for percentage yield, drug content, saturation solubility and in-vitro dissolution studies. Results: The result showed increased solubility and in-vitro drug release of CT compared to the pure drug. The solubility of cefixime trihydrate was enhanced 6 times by using two hydrotropes. Conclusion: In this work, it was concluded that the use of two hydrotropes gave an effective and safe approach to the solubility enhancement of CT. Hence, we can say that hydrotropic techniques can be used to improve the solubility of cefixime trihydrate. INTRODUCTION:Improving the solubility of the poorly aqueous soluble drug is one of the major current difficulties in the pharmaceutical sciences. The bioavailability of the drug depends on the dissolution rate and solubility, which can affect the drug's therapeutic activity. Various factors affect the solubility of a drug i.e temperature, molecular size, pressure, polymorph form, pH of solvent, nature of solute and solvent, porosity, etc.