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Sandsdalen, Erling; Haug, Tor; Stensvåg, Klara; Styrvold, Olaf B.

doi:10.1023/a:1026052715260

Cited by 69 publications

(15 citation statements)

References 28 publications

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“…The high level of activity displayed by extracts and compounds from Fucus vesiculosus has been documented in previous studies 21–23 . For example a polyhydroxylated fucophloroethol extract from Fucus vesiculosus was found to inhibit the growth of S. aureus 24 among other strains, which shows potential for its’ use against MRSA.…”

Section: Discussionsupporting

confidence: 56%

The Screening and Evaluation of Fucus serratus and Fucus vesiculosus Extracts against Current Strains of MRSA Isolated from a Clinical Hospital Setting

Hoare

Tan

McLoughlin

et al. 2019

Sci Rep

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Antimicrobial resistant strains of infection are afflicting clinical settings, driving the search for novel antimicrobial compounds. Naturally sourced bioactives, for instance those from seaweeds, have the potential to ameliorate this issue. As such, solvent extracts from the edible Irish seaweeds Fucus serratus and Fucus vesiculosus were screened for antimicrobial activity against 28 clinically isolated strains of MRSA, including one GISA (glycopeptide intermediate S. aureus) and two mecC gene containing strains. The water extract of F. vesiculosus was the most promising extract went on to be tested for biofilm prevention and disruption activity. The disk diffusion method was used to investigate the inhibition of the bacterial pathogens tested while MIC, MBC and biofilm disruption and prevention analyses were performed spectroscopically and by plate counts, respectively. Solvent extracts were found to have a wide array of antimicrobial activity against the strains tested, with the water extract from Fucus vesiculosus being the most promising. This extract was also found to both prevent and disrupt MRSA biofilms indicating the potential extract as new antimicrobials, and raising the possibility of their possible use in therapeutics.

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Section: Discussionsupporting

confidence: 56%

The Screening and Evaluation of Fucus serratus and Fucus vesiculosus Extracts against Current Strains of MRSA Isolated from a Clinical Hospital Setting

Hoare

Tan

McLoughlin

et al. 2019

Sci Rep

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“…Yet, some positive results in this field have already been reported. Indeed, Sandsdalen et al [141] have shown that a fucophlorethol derivative isolated from F. vesiculosus was a potent bactericidal agent against both Gram-positive ( Staphylococcus aureus , Staphylococcus epidermidis ) and Gram-negative ( Escherichia coli , Proteus mirabilis , Pseudomonas aeruginosa ) bacteria, reducing their growth by 85% compared to the controls. Likewise, the phlorotannins purified from F. spiralis acetone 70% extract showed antibacterial effects against Gram-positive bacteria, exhibiting minimum inhibitory concentrations of 2 mg/mL for Micrococcus luteus , 2 mg/mL for S. epidermidis , 7.8 mg/mL for S. aureus and Bacillus cereus and 15.6 mg/mL for Enterococcus faecalis , while no activity was observed for the Gram-negative ones [142].…”

Section: Biological Activitiesmentioning

confidence: 99%

Fucaceae: A Source of Bioactive Phlorotannins

Catarino

Silva

Cardoso

2017

IJMS

112

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Fucaceae is the most dominant algae family along the intertidal areas of the Northern Hemisphere shorelines, being part of human customs for centuries with applications as a food source either for humans or animals, in agriculture and as remedies in folk medicine. These macroalgae are endowed with several phytochemicals of great industrial interest from which phlorotannins, a class of marine-exclusive polyphenols, have gathered much attention during the last few years due to their numerous possible therapeutic properties. These compounds are very abundant in brown seaweeds such as Fucaceae and have been demonstrated to possess numerous health-promoting properties, including antioxidant effects through scavenging of reactive oxygen species (ROS) or enhancement of intracellular antioxidant defenses, antidiabetic properties through their acarbose-like activity, stimulation of adipocytes glucose uptake and protection of β-pancreatic cells against high-glucose oxidative stress; anti-inflammatory effects through inhibition of several pro-inflammatory mediators; antitumor properties by activation of apoptosis on cancerous cells and metastasis inhibition, among others. These multiple health properties render phlorotannins great potential for application in numerous therapeutical approaches. This review addresses the major contribution of phlototannins for the biological effects that have been described for seaweeds from Fucaceae. In addition, the bioavailability of this group of phenolic compounds is discussed.

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“…Apart from the polysaccharides, antiviral fatty acids, alkaloids, and terpenes have also been isolated from algae [11,12]. Seaweeds contain a large number of antibacterial compounds such as fatty acids [13][14][15], phenols [16,17], and steroids [18][19][20]. Several antibacterial fatty acids are known in the red alga Gloiopeltis furcata [13,14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antimicrobial Activities of Seaweed Resources from Zhejiang Coast, China

Sun

et al. 2018

Sustainability

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In order to utilize seaweeds as a natural therapeutic agent in aquatic cultures, it is important to evaluate their antimicrobial activities. We analyzed that of the typical seaweeds of the Zhejiang Coast in order to improve their potential utilization. Six species of seaweeds were collected from the Zhejiang coast-Ulva pertusa, Ulva prolifera, Gloiopeltis furcata, Gracilariopsis lemaneiformis, Sargassum fusiforme and Ishige okamurae-and their ethanolic extracts were tested for antibacterial effects as well as antiviral activity against the white spot syndrome virus (WSSV). The seaweed extracts inhibited bacterial growth in vitro, and increased the immune responsiveness and survival of the crab Scylla paramamosain infected with WSSV in a concentration-dependent manner. U. prolifera, G. lemaneiformis, and S. fusiforme showed the most potent antibacterial activities and most significant enhancement of the innate immunity in healthy crabs. In conclusion, our study showed that the seaweed extracts have therapeutic effects and are a potential natural medicine for aquatic animals.

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Cited by 69 publications

References 28 publications

The Screening and Evaluation of Fucus serratus and Fucus vesiculosus Extracts against Current Strains of MRSA Isolated from a Clinical Hospital Setting

The Screening and Evaluation of Fucus serratus and Fucus vesiculosus Extracts against Current Strains of MRSA Isolated from a Clinical Hospital Setting

Fucaceae: A Source of Bioactive Phlorotannins

Evaluation of Antimicrobial Activities of Seaweed Resources from Zhejiang Coast, China

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