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Akiyama, Yohko; Nagahara, Naoki; Kashihara, Toshio; Hirai, Shinichiro; Toguchi, Hajime

doi:10.1023/a:1016208703380

Cited by 125 publications

(19 citation statements)

References 17 publications

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“…Macromolecules introduced via paracellular permeability can be increased by using polymeric materials such as chitosan, starch, or poly(acrylate). 109,110 The absorption of nanoparticles via the endocytotic pathway is either by receptor-mediated endocytosis ( i. e . active targeting) or by adsorptive endocytosis, where the ligands do not take part.…”

Section: Nanomedicine As An Emerging Therapeutic Approach For Real mentioning

confidence: 99%

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation

et al. 2013

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The advent of nanotechnology has reignited interest in the field of pharmaceutical science for the development of nanomedicine. Nanomedicinal formulations are nanometer-sized carrier materials designed for increasing the drug tissue bioavailability, thereby improving the treatment of systemically applied chemotherapeutic drugs. Nanomedicine is a new approach to deliver the pharmaceuticals through different routes of administration with safer and more effective therapies compared to conventional methods. To date, various kinds of nanomaterials have been developed over the years to make delivery systems more effective for the treatment of various diseases. Even though nanomaterials have significant advantages due to their unique nanoscale properties, there are still significant challenges in the improvement and development of nanoformulations with composites and other materials. Here in this review, we highlight the nanomedicinal formulations aiming to improve the balance between the efficacy and the toxicity of therapeutic interventions through different routes of administration and how to design nanomedicine for safer and more effective ways to improve the treatment quality. We also emphasize the environmental and health prospects of nanomaterials for human health care.

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Section: Nanomedicine As An Emerging Therapeutic Approach For Real mentioning

confidence: 99%

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation

et al. 2013

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“…The general benefits of CP are high viscosity at low concentrations, thermal and microbiological resistance, and shelf life. Moreover, this polymer is capable of adhering to the surface of the object by forming functional groups (such as hydrogen bond) that has been used for the application in biological barrier , drug release profiles, buccal , nasal , and intestinal . For example, Garipova et al reported that absorption band is the formation of ionic bonds between carboxyl groups of CP and dimethylamino groups of a terpolymer of N,N‐dimethylaminoethyl methacrylate with methylmethacrylate and butylmethacrylate.…”

Section: Introductionmentioning

confidence: 99%

Surface functionalization of carbon nanotubes by biological adhesive polymers carbopol for developing high‐permittivity polymer composites

Liu

Tang

Zhao

et al. 2019

Vinyl Additive Technology

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Surface functionalization of carbon nanotubes (CNTs) by biological adhesive polymers carbopol (CP) was developed by simply mixing CNT suspension and an aqueous solution of CP without any toxic solvents. CP can be easily coated onto CNTs through hydrogen bonds O C OHÁ Á ÁNH 2 C O and electrostatic interaction between COO on CP and NH 3 + on CNTs. After modification, the surface of the CNT is endowed with a large number of carboxyl groups, which can effectively prevent the reaggregation of CNT by electrostatic repulsion between the ionized carboxyl groups. Hence, highly dispersed functionally modifying CNT by CP (CP-CNT) filler in polydimethylsiloxane (PDMS) matrix can be obtained. More important, with the help of adhesive properties of CP, the interfacial compatibility between fillers and matrix can also be improved. Thus, the CP-CNT/PDMS composites exhibited higher dielectric permittivity comparing with CNT/PDMS composites at the same filler content. We present a potential and green approach of surface functionalization of CNT for preparing high-permittivity polymer composites.

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“…Various attempts have been made to prolong the residence time of the dosage forms within the stomach. [12] Prolongation of the gastric residence time (GRT) of delivery devices could be achieved by promoting adhesion to the mucous membranes,[3] which acted by preventing passage of the microspheres through the pylorus[4] or by maintaining them in a buoyant fashion in gastric juice. [5–7] With regard to the floating devices, Innuccelli et al ,[8–10] reported that an air-contained multiple-unit compartment system showed excellent buoyancy in vitro and prolonged GRT relative to the controls in vivo in the fed state.…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro Characterization of Porous Carrier-Based Glipizide Floating Microspheres for Gastric Delivery

Pandya¹,

Pandya²,

Bhaskar³

2011

Journal of Young Pharmacists

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Floating microspheres have been utilized to obtain prolonged and uniform release of drug in the stomach for development of once-daily formulations. A controlled-release system designed to increase residence time in the stomach without contact with the mucosa was achieved through the preparation of floating microspheres by the emulsion solvent diffusion technique, using (i) calcium silicate (CS) as porous carrier; (ii) glipizide, an oral hypoglycemic agent; and (iii) Eudragit® S as polymer. The effects of various formulations and process variables on the internal and external particle morphology, micromeritic properties, in vitro floating behavior, drug loading, and in vitro drug release were studied. The microspheres were found to be regular in shape and highly porous. The prepared microspheres exhibited prolonged drug release (~8 h) and remained buoyant for >10 h. The mean particle size increased and the drug release rate decreased at higher polymer concentrations. No significant effect of the stirring rate during preparation on drug release was observed. In vitro studies demonstrated diffusion-controlled drug release from the microspheres. Microsphere formulation CS4, containing 200 mg calcium silicate, showed the best floating ability (88% buoyancy) in simulated gastric fluid. The release pattern of glipizide in simulated gastric fluid from all floating microspheres followed the Higuchi matrix model and the Peppas-Korsmeyer model.

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Cited by 125 publications

References 17 publications

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation

Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation

Surface functionalization of carbon nanotubes by biological adhesive polymers carbopol for developing high‐permittivity polymer composites

Preparation and in vitro Characterization of Porous Carrier-Based Glipizide Floating Microspheres for Gastric Delivery

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