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Pietra, Anna Maria Di; Cavrini, Vanni; Gatti, Rita; Raggi, MA

doi:10.1023/a:1015955811112

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…The application for detection of traces of benzaldehyde in benzyl alcohol was proven. Our method in comparison to other electrochemical 3 and bioelectrochemical 13 methods is oxygen independent and does not need addition of NAD + , and it is fast and easy in comparison to other alternative methods for benzaldehyde measurement using HPLC/UV 2, 8, 9, SPR‐immunosensor 11, chemiluminescence 10 yielding to almost no one in the respect of analytical characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…The classical methods of benzaldehyde detection are based on gravimetry, gas and high‐performance liquid chromatography, and spectrophotometry coupled with additional signal amplification reaction 1, 2, 7–9. Traces of benzaldehyde in benzyl alcohol were also determined by differential pulse voltammetry on mercury drop electrodes 3 and by chemiluminescence 10.…”

Section: Introductionmentioning

confidence: 99%

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A Biosensor for Aromatic Aldehydes Comprising the Mediator Dependent PaoABC‐Aldehyde Oxidoreductase

et al. 2012

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A novel aldehyde oxidoreductase (PaoABC) from Escherichia coli was utilized for the development of an oxygen insensitive biosensor for benzaldehyde. The enzyme was immobilized in polyvinyl alcohol and currents were measured for aldehyde oxidation with different one and two electron mediators with the highest sensitivity for benzaldehyde in the presence of hexacyanoferrate(III). The benzaldehyde biosensor was optimized with respect to mediator concentration, enzyme loading and pH using potassium hexacyanoferrate(III). The linear measuring range is between 0.5–200 µM benzaldehyde. In correspondence with the substrate selectivity of the enzyme in solution the biosensor revealed a preference for aromatic aldehydes and less effective conversion of aliphatic aldehydes. The biosensor is oxygen independent, which is a particularly attractive feature for application. The biosensor can be applied to detect contaminations with benzaldehyde in solvents such as benzyl alcohol, where traces of benzaldehyde in benzyl alcohol down to 0.0042 % can be detected.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Biosensor for Aromatic Aldehydes Comprising the Mediator Dependent PaoABC‐Aldehyde Oxidoreductase

et al. 2012

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“… [39] . In all the experiments, benzaldehyde and benzoic acid were detected by HPLC methods [46,47] after 30 minutes (an induction time). This confirmed the formation of benzaldehyde which in turn was further oxidized to benzoic acid.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of 3‐(Aryl azo)‐4‐hydroxy‐1,2‐naphthoquinone Ruthenium(III) Complexes as Catalysts for Benzyl Alcohol Oxidation

Almalki

2021

ChemistrySelect

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The syntheses and characterization of 3‐(p‐substituted phenyl azo)‐4‐hydroxy‐l,2‐naphthoquinones ligands (L1‐3) and their Ru(III) complexes (Ru1‐3) are carried out. The characterization was ascertained by elemental analysis, thermal analysis, spectroscopic analyses (FT‐IR, 1H NMR, UV‐vis and Mass), magnetic, molar conductance, molecular calculations and electrochemical techniques. The green catalytic conversion of some benzyl alcohols to benzoic acid derivatives was successfully achieved by using these complexes in an aqueous KOH with K2S2O8 as co‐oxidant; with high yields by using Ru3 complex. Computational modeling was carried out to predict the structural geometry, magnetic characters and the electron donor/acceptor functions of the prepared complexes along with experimental results. The mechanism of benzyl alcohol oxidation was developed through an orange ruthenate‐persulfate reagent. The oxidation capacities of the ruthenium complexes were better than the other catalysts reported. The present results are useful to oxidize benzyl alcohols at an industrial scale with a good economy.

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“…The literature review, reveals that various methods of analysis are available for triamcinolone acetonide [4][5][6][7] and benzyl alcohol [8][9][10][11][12][13][14][15] determination with different formulations or drug matrices, only one method is available for the tablet or pure form of simultaneous estimation, in which force degradation and recovery studies are performed on standard prepared in diluent instead of placebo which does not meet FDA or ICH guidelines criteria to show, specificity or interference due to placebo occurs with the main component [16][17][18] and also in previous methods mobile phase is made by mixing a buffer of adjusted pH with organic to the desired ratio which is a tedious or time-consuming task when analyzing a large number of samples. Buffer in the mobile phase reduces column life and increases the cost of analysis.…”

Section: Introductionmentioning

confidence: 99%

Development of a Validated High-Performance Liquid Chromatographic Method in Reverse Phase for Simultaneously Determining Triamcinolone Acetonide and Benzyl Alcohol in Injectable Suspension.

Tiwari

Mishra²

2021

Orient. J. Chem

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A high-performance liquid chromatographic stability-indicating assaymethod in reverse-phase has been developed and validated for the simultaneous qualitative and quantitative measurement of triamcinolone acetonide and benzyl alcohol content in injectable suspension. The reverse-phase method was developed by using Inertsil ODS-2 column(100 x 4.6mm),5μm. with a mobile phase ratio comprised of water and acetonitrile mixed in 70:30 v/v ratio and pumped at a flow rate of 1.5 ml/min where the temperature of the column oven controlled at 40°C and sample compartment at 5°C with 10μL injection volume. Benzyl Alcohol and Triamcinolone Acetonide had retention times of 1.80 and 5.60 minutes, respectively with UV detection for benzyl alcohol at 215 nm and triamcinolone acetonide at 254 nm. The guidelines of the International Conference on Harmonization were used for the validation of this novel method. During validation, the developed approach was shown to be exact, accurate, linear, robust, rugged, and stable. The detector was showing linear response in a range of 10 µg/mlto 120 µg/ml and 2.5 µg/ml to 30 µg/ml for triamcinolone Acetonide and benzoyl alcohol respectively.

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Untitled

Cited by 12 publications

References 16 publications

A Biosensor for Aromatic Aldehydes Comprising the Mediator Dependent PaoABC‐Aldehyde Oxidoreductase

A Biosensor for Aromatic Aldehydes Comprising the Mediator Dependent PaoABC‐Aldehyde Oxidoreductase

Synthesis and Characterization of 3‐(Aryl azo)‐4‐hydroxy‐1,2‐naphthoquinone Ruthenium(III) Complexes as Catalysts for Benzyl Alcohol Oxidation

Development of a Validated High-Performance Liquid Chromatographic Method in Reverse Phase for Simultaneously Determining Triamcinolone Acetonide and Benzyl Alcohol in Injectable Suspension.

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