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Ia, Volchegorskiĭ; Se, Shemyakov; Vv, Turygin; Nv, Malinovskaya

doi:10.1023/a:1013081912452

Cited by 15 publications

(8 citation statements)

References 3 publications

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“…The observed age-related increase in catalase activity can be considered as a compensatory reaction aimed at the maintenance of antioxidant defense of the brain under conditions of ontogenetic MAO-B dependent decrease in Cu,Zn-SOD activity [5]. This compensation is most effective in the cortex, where the age-related increase in catalase activity was in general comparable or surpassed the ontogenetic increase in MAO-B activity and concomitant decrease in Cu,Zn-SOD activity.…”

Section: Resultsmentioning

confidence: 91%

“…Evident reciprocal nature of the ontogenetic dynamics of Cu,Zn-SOD and MAO-B activities correspond to the pattern of age-related changes in activities of these enzymes in the brain and spinal cord of aging individuals [3,5]. This is probably determined by activation of MAO-B-dependent production of H 2 O 2 acting as a Cu,Zn-SOD inhibitor [6].…”

Section: Resultsmentioning

confidence: 99%

“…This is probably determined by activation of MAO-B-dependent production of H 2 O 2 acting as a Cu,Zn-SOD inhibitor [6]. In view of age-related decrease in Cu,Zn-SOD activity in the brain, of particular interest are ontogenetic shifts in cerebral content of EACP, which is considered to be a SOD-like factor of antioxidant defense in the brain [5]. In the majority of brain structures, the content of EACP in newborns increased 1.4-1.9-fold compared to fetal values; then this parameter gradually decreased remaining above the fetal values until juvenile age and attaining the prenatal values in adolescents (Table 1-3).…”

Section: Resultsmentioning

confidence: 99%

“…The cerebral content of this enzyme in humans increases during aging [5]. The age-related increase in cerebral MAO-B during the late ontogeny is accompanied by pronounced decrease in Cu,Zn-SOD activity and resistance to oxidative stress (OS) and accumulation of LPO products in various parts of the brain [4,5]. Therefore, ontogenetic increase in MAO-B activity can be considered as a key mechanism of age-related involution of cerebral structures.…”

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confidence: 99%

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Dynamics of activity of monoamine oxidase B and antioxidant defense enzymes in human brain during postnatal ontogeny

et al. 2006

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During postnatal development, activity of monoamine oxidase B in human brain structures increases, while activity of Cu,Zn-dependent SOD decreases with compensatory increase in catalase activity and ceruloplasmin content. Under these conditions, the resistance of the pontobulbar structures and thalamus to oxidative stress decreases at the age of 1-12 years and returned to the prenatal level during adolescence. The increase in catalase activity is most pronounced in structures of the forebrain (cortex and neostriatum), cerebellum, and hypothalamus; it is accompanied by ontogenetic increase in oxidative stress resistance, which is maximum at the age of 12-21 years. The maintenance of resistance to oxidative stress (depends on monoamine oxidase B) can be considered as an important condition of structural and functional maturation of cerebral structures during the postnatal ontogeny.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Dynamics of activity of monoamine oxidase B and antioxidant defense enzymes in human brain during postnatal ontogeny

et al. 2006

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“…This regularity is assumed to result from agespecific increase in activity of monoamine oxidase B, concomitant reduction of Cu,Zn-dependent SOD activity, and insufficient compensatory increase in activities of catalase and ceruloplasmin in the brain and thoracic compartment of the spinal cord [2,4]. H 2 O 2 , a substrate-independent product of monoamine oxidase reaction, is characterized by Cu,Zn-SOD-inhibitory effect and LPO-inducing activity.…”

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confidence: 99%

Dynamics of LPO products and oxidative modification of proteins in human brain during postnatal development

et al. 2007

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Opposite changes in the content of LPO products and products of oxidative modification of proteins were detected in human brain structures in the course of postnatal development. A clear-cut ontogenetic reduction of LPO products was observed in field 17 of the cortex, archicortex structures, and in the hypothalamus. Age-specific increase in the levels of products of oxidative modification of proteins was recorded in all compartments of the brain; it peaked by the age of 12-21 years and was most pronounced (4-6-fold) in the visual cortex, hippocampus, diencephalic and pontobulbar compartments of the brain.

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Beneficial effect of yam on the amyloid β‐protein, monoamine oxidase B and cognitive deficit in mice with accelerated senescence

et al. 2006

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This study was designed to evaluate the effect of yam tuber material [Dioscorea alata L. var. purpurea (M.) Pouch.] on the amyloid β-protein (Aβ) accumulation, monoamine oxidase (MAO) activity, cognitive ability and antioxidative defense system in senescence-accelerated mice (SAMP8). Three-month-old male mice were fed with four different diets for 12 weeks: a casein diet (control group) and a casein diet supplemented with either 100, 200 or 400 g kg −1 lyophilized yam. The results of the active shuttle avoidance test showed that the mice fed with the yam-containing diets had significantly better learning and memory ability than the control group. All yam-containing diet groups had lower Aβ levels and MAO B activities than the control, whereas the MAO A activity did not differ among the four diet groups. At the 400 g kg −1 level, the yam-containing diet group showed significantly lower concentration of thiobarbituric acid-reactive substances (TBARS), higher total thiol level and superoxide dismutase (SOD) activity in the hippocampus than the control, but these values were not altered by the 100 and 200 g kg −1 yam-containing diet groups. The addition of 200 or 400 g kg −1 yam also lowered the triglyceride levels but not the total cholesterol concentration. These results indicate that lyophilized yam could reduce brain Aβ accumulation, MAO B activity and cognitive deficits and promote the antioxidative defense system in SAMP8 mice. The improvements were in a dose-dependent manner, possibly because the 400 g kg −1 yam-containing diet might contain more antioxidative phytochemicals.

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Cited by 15 publications

References 3 publications

Dynamics of activity of monoamine oxidase B and antioxidant defense enzymes in human brain during postnatal ontogeny

Dynamics of activity of monoamine oxidase B and antioxidant defense enzymes in human brain during postnatal ontogeny

Dynamics of LPO products and oxidative modification of proteins in human brain during postnatal development

Beneficial effect of yam on the amyloid β‐protein, monoamine oxidase B and cognitive deficit in mice with accelerated senescence

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