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doi:10.13040/ijpsr.0975-8232.12(1).95-103

Cited by 2 publications

(11 citation statements)

References 15 publications

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“…Simultaneously, keeping serum concentrations low reduces adverse reactions, further improving patient compliance [ 17 ]. Microencapsulation, producing 0.5–1 mm diameter microbeads, is an attractive CTDDS method [ 17 , 18 , 19 ]. It also improves oral curcumin’s sensory experience by eliminating the bitter taste without altering its nature [ 20 ].…”

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

“…Any drug delivery system should aim to achieve and maintain the target therapeutic drug concentration at the site in the body. This can be accomplished using a multiparticulate dosage form like microbeads or nanoparticles, which are divided into smaller subunits that each have the desired properties [ 19 ]. Microencapsulation is an attractive, advanced process commonly used to produce controlled drug release systems [ 19 , 25 ].…”

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

“…This can be accomplished using a multiparticulate dosage form like microbeads or nanoparticles, which are divided into smaller subunits that each have the desired properties [ 19 ]. Microencapsulation is an attractive, advanced process commonly used to produce controlled drug release systems [ 19 , 25 ]. It involves the permanent or temporary coating of an unstable active substance with a polymeric or nonpolymeric material.…”

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

“…It enables controlled or sustained drug release at a particular location in the body over time and under desired environmental conditions. This preserves an adequate drug amount to have the intended effect at a specific site [ 19 , 26 , 27 ]. Subsequently, core substance stability is improved, along with enhanced efficiency in factors like dose-dependent antioxidant and anti-inflammatory effects.…”

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

“…Subsequently, core substance stability is improved, along with enhanced efficiency in factors like dose-dependent antioxidant and anti-inflammatory effects. Bioavailability is also boosted, reducing dosing frequency and dose amount while maintaining uniform delivery [ 19 , 20 , 25 , 30 ]. The coating material type is crucial in this regard [ 27 ].…”

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

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The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present

Azad,

Lai,

Sulaiman

et al. 2024

Pharmaceutics

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Turmeric contains curcumin, a naturally occurring compound with noted anti-inflammatory and antioxidant properties that may help fight cancer. Curcumin is readily available, nontoxic, and inexpensive. At high doses, it has minimal side effects, suggesting it is safe for human use. However, curcumin has extremely poor bioavailability and biodistribution, which further hamper its clinical applications. It is commonly administered through oral and transdermal routes in different forms, where the particle size is one of the most common barriers that decreases its absorption through biological membranes on the targeted sites and limits its clinical effectiveness. There are many studies ongoing to overcome this problem. All of this motivated us to conduct this review that discusses the fabrication of polymer-based curcumin-loaded formulation as an advanced drug delivery system and addresses different approaches to overcoming the existing barriers and improving its bioavailability and biodistribution to enhance the therapeutic effects against cancer and other diseases.

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Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

Section: Approaches To Overcoming Existing Barriers Of Curcuminmentioning

confidence: 99%

See 3 more Smart Citations

The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present

Azad,

Lai,

Sulaiman

et al. 2024

Pharmaceutics

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Alginate Microbeads Technology for Pharmaceutical Applications

B. Medha Gayatri,

A. V. Vasanthi

2024

IJARSCT

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Nowadays, microbeads are inevitable in pharmaceutical formulations with remarkable drug delivery and therapeutic outcome benefits. Usually made from biocompatible polymers, these tiny spherical particles allow for controlled and targeted delivery of APIs within the human body. Other benefits associated with microbeads include their ability to control drug release kinetics in terms of sustained or pulsatile release profiles in order to facilitate patient compliance and minimize adverse effects. This also has a minimal size and allows for adaptation for precise dosing and targeting the right sites, which augments therapeutic efficacy while cutting down systemic exposure. The need for safe and effective drug delivery systems has been a crucial aspect in the advancement of new pharmaceutical formulations. Researchers continue to seek new ways in prolonging drug release, minimizing drug wastage, and reducing the side effects of drugs. However, synthetic polymers are costly, non-biocompatible, and potentially toxic. On the other hand, sodium alginate, a natural polymer, is generally used as a matrix material because of biodegradability, low price, simplicity, and excellent biocompatibility. Sodium alginate is nontoxic when delivered orally and gives protection on the mucous membrane of the upper gastrointestinal tract. Sodium alginate is an anionic polysaccharide of natural origin wherein gelation can be obtained with the use of calcium ions to form stable microbeads. There are multiple techniques used to prepare alginate microbeads, that is, ionotropic gelation, cross-linking, emulsion gelation, spray drying, and both simple and complex coacervation phase separation methods. This review shall highlight the preparation and characterization of alginate microbeads, their therapeutic applications, and their position in the realm of controlled and novel drug delivery systems

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Cited by 2 publications

References 15 publications

The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present

The Fabrication of Polymer-Based Curcumin-Loaded Formulation as a Drug Delivery System: An Updated Review from 2017 to the Present

Alginate Microbeads Technology for Pharmaceutical Applications

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